Comparison of diazepam and midazolam for sedation during local anaesthesia for bronchoscopy. 1985

K Korttila, and J Tarkkanen

Bronchoscopy was performed in 76 outpatients using local anaesthesia plus diazepam 0.2 mg kg-1 i.v. or midazolam 0.05 or 0.1 mg kg-1 i.v. Patient co-operation and ease of bronchoscopy were good in all patients. Two hours after injection, 67% (diazepam 0.2 mg kg-1), 36% (midazolam 0.05 mg kg-1) and 75% (midazolam 0.1 mg kg-1) of the patients failed to recall the insertion of the bronchoscope. Similarly, when asked on the following day, only 22%, 52% and 8%, respectively, of the patients remembered bronchoscopy. Two hours after sedation, the patients' performances in three psychomotor tests were similar to those measured before sedation in each group, but the patients' ability to stand steadily and walk along a straight line reverted to normal significantly (P less than 0.05) more slowly in patients receiving midazolam 0.1 mg kg-1 than in the patients given diazepam. The results suggest that midazolam offers no advantage over diazepam in terms of speed of recovery of psychomotor function, when doses of similar potency are given for bronchoscopy.

UI MeSH Term Description Entries
D006993 Hypnotics and Sedatives Drugs used to induce drowsiness or sleep or to reduce psychological excitement or anxiety. Hypnotic,Sedative,Sedative and Hypnotic,Sedatives,Hypnotic Effect,Hypnotic Effects,Hypnotics,Sedative Effect,Sedative Effects,Sedatives and Hypnotics,Effect, Hypnotic,Effect, Sedative,Effects, Hypnotic,Effects, Sedative,Hypnotic and Sedative
D008297 Male Males
D008568 Memory Complex mental function having four distinct phases: (1) memorizing or learning, (2) retention, (3) recall, and (4) recognition. Clinically, it is usually subdivided into immediate, recent, and remote memory.
D008874 Midazolam A short-acting hypnotic-sedative drug with anxiolytic and amnestic properties. It is used in dentistry, cardiac surgery, endoscopic procedures, as preanesthetic medication, and as an adjunct to local anesthesia. The short duration and cardiorespiratory stability makes it useful in poor-risk, elderly, and cardiac patients. It is water-soluble at pH less than 4 and lipid-soluble at physiological pH. Dormicum,Midazolam Hydrochloride,Midazolam Maleate,Ro 21-3981,Versed,Hydrochloride, Midazolam,Maleate, Midazolam,Ro 21 3981,Ro 213981
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D011597 Psychomotor Performance The coordination of a sensory or ideational (cognitive) process and a motor activity. Perceptual Motor Performance,Sensory Motor Performance,Visual Motor Coordination,Coordination, Visual Motor,Coordinations, Visual Motor,Motor Coordination, Visual,Motor Coordinations, Visual,Motor Performance, Perceptual,Motor Performance, Sensory,Motor Performances, Perceptual,Motor Performances, Sensory,Perceptual Motor Performances,Performance, Perceptual Motor,Performance, Psychomotor,Performance, Sensory Motor,Performances, Perceptual Motor,Performances, Psychomotor,Performances, Sensory Motor,Psychomotor Performances,Sensory Motor Performances,Visual Motor Coordinations
D001999 Bronchoscopy Endoscopic examination, therapy or surgery of the bronchi. Bronchoscopic Surgical Procedures,Surgical Procedures, Bronchoscopic,Bronchoscopic Surgery,Surgery, Bronchoscopic,Bronchoscopic Surgeries,Bronchoscopic Surgical Procedure,Bronchoscopies,Surgeries, Bronchoscopic,Surgical Procedure, Bronchoscopic
D003975 Diazepam A benzodiazepine with anticonvulsant, anxiolytic, sedative, muscle relaxant, and amnesic properties and a long duration of action. Its actions are mediated by enhancement of GAMMA-AMINOBUTYRIC ACID activity. 7-Chloro-1,3-dihydro-1-methyl-5-phenyl-2H-1,4-benzodiazepin-2-one,Apaurin,Diazemuls,Faustan,Relanium,Seduxen,Sibazon,Stesolid,Valium
D005260 Female Females
D006439 Hemodynamics The movement and the forces involved in the movement of the blood through the CARDIOVASCULAR SYSTEM. Hemodynamic

Related Publications

K Korttila, and J Tarkkanen
April 1986, British journal of anaesthesia,
K Korttila, and J Tarkkanen
November 1983, British journal of anaesthesia,
K Korttila, and J Tarkkanen
May 1988, Plastic and reconstructive surgery,
K Korttila, and J Tarkkanen
January 1982, Acta anaesthesiologica Belgica,
K Korttila, and J Tarkkanen
January 1987, Acta anaesthesiologica Belgica,
K Korttila, and J Tarkkanen
January 1990, British journal of anaesthesia,
K Korttila, and J Tarkkanen
January 1984, Annales francaises d'anesthesie et de reanimation,
K Korttila, and J Tarkkanen
December 2009, Indian journal of anaesthesia,
K Korttila, and J Tarkkanen
May 1978, Canadian Anaesthetists' Society journal,
Copied contents to your clipboard!