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The luteinizing hormone releasing hormone, Zoladex, has been used in three centres, Pontefract, Antwerp and Mistelbach, to treat carcinoma of the prostate. An initial protocol using a soluble daily injection has been followed by a second study employing a monthly administered depot preparation. After an initial stimulation it has been shown that both daily and monthly injections reduce plasma testosterone to castrate levels. Circulating luteinizing hormone levels are also initially stimulated and then suppressed. Treatment toxicity has been minimal and in these short term studies reduction of acid phosphatase and subjective and objective tumour responses have been similar to those expected from effective hormonal therapy of prostatic cancer.
M R Robinson, and
L Denis, and
C Mahler, and
K Walker, and
R Stitch, and
G Lunglmayr
January 1987,
Hinyokika kiyo. Acta urologica Japonica,
M R Robinson, and
L Denis, and
C Mahler, and
K Walker, and
R Stitch, and
G Lunglmayr
October 1986,
Hinyokika kiyo. Acta urologica Japonica,
M R Robinson, and
L Denis, and
C Mahler, and
K Walker, and
R Stitch, and
G Lunglmayr
January 1990,
Drugs under experimental and clinical research,
M R Robinson, and
L Denis, and
C Mahler, and
K Walker, and
R Stitch, and
G Lunglmayr
April 1986,
Nederlands tijdschrift voor geneeskunde,
M R Robinson, and
L Denis, and
C Mahler, and
K Walker, and
R Stitch, and
G Lunglmayr
January 1987,
Progress in clinical and biological research,
M R Robinson, and
L Denis, and
C Mahler, and
K Walker, and
R Stitch, and
G Lunglmayr
October 1987,
Lakartidningen,
M R Robinson, and
L Denis, and
C Mahler, and
K Walker, and
R Stitch, and
G Lunglmayr
January 1988,
Scandinavian journal of urology and nephrology. Supplementum,
M R Robinson, and
L Denis, and
C Mahler, and
K Walker, and
R Stitch, and
G Lunglmayr
February 1988,
Hinyokika kiyo. Acta urologica Japonica,
M R Robinson, and
L Denis, and
C Mahler, and
K Walker, and
R Stitch, and
G Lunglmayr
May 2001,
Hinyokika kiyo. Acta urologica Japonica,
M R Robinson, and
L Denis, and
C Mahler, and
K Walker, and
R Stitch, and
G Lunglmayr
January 1998,
Urologia internationalis,
