-transparent.png){kind=logo}
A study was undertaken on the immunomodulating properties of pentamidine, a diamidine used in the treatment of African trypanosomiasis, pneumocystosis and leishmaniasis. Pentamidine inhibited the ability of mouse splenic lymphocytes to respond to mitogens. In particular inhibition of the B lymphocyte response was observed. At concentrations of 1 microgram/ml (1.7 x 10(-6) M), pentamidine markedly inhibited the response to the B cell mitogen, lipopolysaccharide (LPS), while concentrations of 10 micrograms/ml had to be attained to produce a similar effect on the response to the T cell mitogens phytohaemagglutinin (PHA) and concanavalin A (ConA). Further studies showed that pentamidine was not toxic to either resting or proliferating cells and probably acts by interacting directly with B cells rather than modifying the regulatory cell populations.
A Ferrante, and
L K Secker, and
Y H Thong
October 2009,
Phytomedicine : international journal of phytotherapy and phytopharmacology,
A Ferrante, and
L K Secker, and
Y H Thong
December 1987,
Journal of immunology (Baltimore, Md. : 1950),
A Ferrante, and
L K Secker, and
Y H Thong
January 1979,
Cellular immunology,
A Ferrante, and
L K Secker, and
Y H Thong
July 1976,
Journal of immunology (Baltimore, Md. : 1950),
A Ferrante, and
L K Secker, and
Y H Thong
November 1989,
Immunology,
A Ferrante, and
L K Secker, and
Y H Thong
November 1984,
Infection and immunity,
A Ferrante, and
L K Secker, and
Y H Thong
September 1976,
The Journal of experimental medicine,
A Ferrante, and
L K Secker, and
Y H Thong
October 1983,
Gan to kagaku ryoho. Cancer & chemotherapy,
A Ferrante, and
L K Secker, and
Y H Thong
January 1990,
Immunopharmacology and immunotoxicology,
A Ferrante, and
L K Secker, and
Y H Thong
October 1977,
Antimicrobial agents and chemotherapy,
