Biomaterial Database

Rosetting of human T lymphocytes with goat red blood cells: effect of treatment with 2-aminoethylisothiouronium bromide (AET) and comparison with AET treated sheep red blood cells. 1979

F Indiveri, and M A Pellegrino, and G A Molinaro, and V Quaranta, and S Ferrone

In vitro treatment of goat red blood cells (GRBCs) with the sulphydryl compound 2-aminoethylisothiouronium bromide (AET) increases their specific reactivity with human T lymphocytes without affecting the specificity of the reaction. AET-GRBCs bind to only part of T lymphocytes rosetting with AET-sheep red blood cells (SRBCs): the receptors for both types of RBCs are very simular if not identical, but display higher affinity for AET-SRBCs than for AET-GRBCs. Rosetting of T lymphocytes with AET-GRBCs may be useful to enumerate T lymphocyte subsets in patients with abnormality of the immune system and to fractionate T lymphocyte subpopulations.

UI	MeSH Term	Description	Entries
D007106	Immune Sera	Serum that contains antibodies. It is obtained from an animal that has been immunized either by ANTIGEN injection or infection with microorganisms containing the antigen.	Antisera,Immune Serums,Sera, Immune,Serums, Immune
D004912	Erythrocytes	Red blood cells. Mature erythrocytes are non-nucleated, biconcave disks containing HEMOGLOBIN whose function is to transport OXYGEN.	Blood Cells, Red,Blood Corpuscles, Red,Red Blood Cells,Red Blood Corpuscles,Blood Cell, Red,Blood Corpuscle, Red,Erythrocyte,Red Blood Cell,Red Blood Corpuscle
D006041	Goats	Any of numerous agile, hollow-horned RUMINANTS of the genus Capra, in the family Bovidae, closely related to the SHEEP.	Capra,Capras,Goat
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000338	beta-Aminoethyl Isothiourea	A radiation-protective agent that can inhibit DNA damage by binding to the DNA. It also increases the susceptibility of blood cells to complement-mediated lysis.	2-Aminoethylisothiuronium Bromide,beta-Aminoethylisothiuronium Diacetate,beta-Aminoethylisothiuronium Dihydrobromide,2-Aminoethylisothiuronium Diacetate,2-Aminoethylisothiuronium Dihydrochloride,2-Aminoethylisothiuronium Dihydroiodide,2-Aminoethylisothiuronium Diperchlorate,2-Aminoethylisothiuronium Monohydrobromide,2-Aminoethylisothiuronium Phosphate (1:1),2-Aminoethylisothiuronium Sulfate (1:1),AET,Aminoethylisothiuronium Bromide Hydrobromide,Carbamimidothioic acid, 2-aminoethyl ester, dihydrobromide,Isothiourea, (2-Aminoethyl),Ixecur,S-(2-Aminoethyl)isothiourea,beta-Aminoethylisothiuronium Bromide,beta-Aminoethylisothiuronium Dihydrochloride,beta-Aminoethylisothiuronium Dihydroiodide,beta-Aminoethylisothiuronium Diperchlorate,beta-Aminoethylisothiuronium Monohydrobromide,beta-Aminoethylisothiuronium Phosphate (1:1),beta-Aminoethylisothiuronium Sulfate (1:1),2 Aminoethylisothiuronium Bromide,2 Aminoethylisothiuronium Diacetate,2 Aminoethylisothiuronium Dihydrochloride,2 Aminoethylisothiuronium Dihydroiodide,2 Aminoethylisothiuronium Diperchlorate,2 Aminoethylisothiuronium Monohydrobromide,Bromide, 2-Aminoethylisothiuronium,Bromide, beta-Aminoethylisothiuronium,Diacetate, 2-Aminoethylisothiuronium,Diacetate, beta-Aminoethylisothiuronium,Dihydrobromide, beta-Aminoethylisothiuronium,Dihydrochloride, 2-Aminoethylisothiuronium,Dihydrochloride, beta-Aminoethylisothiuronium,Dihydroiodide, 2-Aminoethylisothiuronium,Dihydroiodide, beta-Aminoethylisothiuronium,Diperchlorate, 2-Aminoethylisothiuronium,Diperchlorate, beta-Aminoethylisothiuronium,Hydrobromide, Aminoethylisothiuronium Bromide,Isothiourea, beta-Aminoethyl,Monohydrobromide, 2-Aminoethylisothiuronium,Monohydrobromide, beta-Aminoethylisothiuronium,beta Aminoethyl Isothiourea,beta Aminoethylisothiuronium Bromide,beta Aminoethylisothiuronium Diacetate,beta Aminoethylisothiuronium Dihydrobromide,beta Aminoethylisothiuronium Dihydrochloride,beta Aminoethylisothiuronium Dihydroiodide,beta Aminoethylisothiuronium Diperchlorate,beta Aminoethylisothiuronium Monohydrobromide
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D001402	B-Lymphocytes	Lymphoid cells concerned with humoral immunity. They are short-lived cells resembling bursa-derived lymphocytes of birds in their production of immunoglobulin upon appropriate stimulation.	B-Cells, Lymphocyte,B-Lymphocyte,Bursa-Dependent Lymphocytes,B Cells, Lymphocyte,B Lymphocyte,B Lymphocytes,B-Cell, Lymphocyte,Bursa Dependent Lymphocytes,Bursa-Dependent Lymphocyte,Lymphocyte B-Cell,Lymphocyte B-Cells,Lymphocyte, Bursa-Dependent,Lymphocytes, Bursa-Dependent
D001665	Binding Sites	The parts of a macromolecule that directly participate in its specific combination with another molecule.	Combining Site,Binding Site,Combining Sites,Site, Binding,Site, Combining,Sites, Binding,Sites, Combining
D012397	Rosette Formation	The in vitro formation of clusters consisting of a cell (usually a lymphocyte) surrounded by antigenic cells or antigen-bearing particles (usually erythrocytes, which may or may not be coated with antibody or antibody and complement). The rosette-forming cell may be an antibody-forming cell, a memory cell, a T-cell, a cell bearing surface cytophilic antibodies, or a monocyte possessing Fc receptors. Rosette formation can be used to identify specific populations of these cells.	Immunocytoadherence,Formation, Rosette,Formations, Rosette,Immunocytoadherences,Rosette Formations
D012756	Sheep	Any of the ruminant mammals with curved horns in the genus Ovis, family Bovidae. They possess lachrymal grooves and interdigital glands, which are absent in GOATS.	Ovis,Sheep, Dall,Dall Sheep,Ovis dalli