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Thirty-seven patients with seborrheic dermatitis were treated topically with a 2% ketoconazole cream or its vehicle control in a double-blind study. The subjects were studied for numbers of Malassezia ovalis (Pityrosporum ovale) cells in their scalp scale; changes in numbers of yeast cells and morphology of M. ovalis were tabulated along with clinical assessment of improvement. The 2% ketoconazole cream, but not the placebo cream, reduced the numbers of viable yeast cells on the scalp. The clinical effect of 2% ketoconazole cream was good (75%-95% improvement) or better in eighteen of twenty subjects; the placebo cream produced good results in only three of seventeen subjects treated. Results of this study are consistent with the view that M. ovalis plays a central role in the pathogenesis of seborrheic dermatitis.
R B Skinner, and
P W Noah, and
R M Taylor, and
M D Zanolli, and
S West, and
J D Guin, and
E W Rosenberg
November 1988,
Journal of the American Academy of Dermatology,
R B Skinner, and
P W Noah, and
R M Taylor, and
M D Zanolli, and
S West, and
J D Guin, and
E W Rosenberg
May 2013,
The Journal of dermatological treatment,
R B Skinner, and
P W Noah, and
R M Taylor, and
M D Zanolli, and
S West, and
J D Guin, and
E W Rosenberg
November 1987,
Giornale italiano di dermatologia e venereologia : organo ufficiale, Societa italiana di dermatologia e sifilografia,
R B Skinner, and
P W Noah, and
R M Taylor, and
M D Zanolli, and
S West, and
J D Guin, and
E W Rosenberg
March 2007,
Journal of the European Academy of Dermatology and Venereology : JEADV,
R B Skinner, and
P W Noah, and
R M Taylor, and
M D Zanolli, and
S West, and
J D Guin, and
E W Rosenberg
January 2013,
Annals of parasitology,
R B Skinner, and
P W Noah, and
R M Taylor, and
M D Zanolli, and
S West, and
J D Guin, and
E W Rosenberg
September 1989,
The British journal of dermatology,
R B Skinner, and
P W Noah, and
R M Taylor, and
M D Zanolli, and
S West, and
J D Guin, and
E W Rosenberg
September 2004,
Journal of the Medical Association of Thailand = Chotmaihet thangphaet,
R B Skinner, and
P W Noah, and
R M Taylor, and
M D Zanolli, and
S West, and
J D Guin, and
E W Rosenberg
November 1991,
International journal of dermatology,
R B Skinner, and
P W Noah, and
R M Taylor, and
M D Zanolli, and
S West, and
J D Guin, and
E W Rosenberg
January 1998,
Journal of the European Academy of Dermatology and Venereology : JEADV,
R B Skinner, and
P W Noah, and
R M Taylor, and
M D Zanolli, and
S West, and
J D Guin, and
E W Rosenberg
June 2017,
International journal of women's dermatology,
