The purpose of this experiment was to investigate handedness and sex differences with regard to the way verbal and spatial information is coded in selective-interference tasks. Left- and right-handed males and females were required to recall both letters and their positions in a matrix under three different kinds of interpolated conditions: visual, auditory, and noninterpolated activities. The results indicated that the selective-interference effect differed in right- and left-handers, whereas there were no differences by sex. Identity information had a dual encoding for both handedness groups, but it was relatively more biased toward visual encoding in left-handers than in right-handers; position information, however, was predominantly visually encoded--and to the same extent--in both handedness groups. These findings were interpreted as supporting the view that the differences in coding manner of right- and left-handers are related to differences in their hemispheric specialization.