Biomaterial Database

Neuronal regulation of group 2 innate lymphoid cells and type 2 inflammation. 2019

Saya Moriyama, and David Artis

Jill Roberts Institute for Research in Inflammatory Bowel Disease, Weill Cornell Medicine, Cornell University, New York, NY, United States.

Diverse infectious, inflammatory, and environmental stimuli induce type 2 inflammation in the body. Group 2 innate lymphoid cells (ILC2s) are potent producers of type 2 cytokines and play important roles in promoting type 2 inflammation. In addition to alarmins and other cytokines which are known to regulate ILC2 responses, emerging studies identified the regulation of ILC2s by the nervous system through neurotransmitter and neuropeptides. In this review, we highlight recent advances in the regulation of ILC2s and type 2 inflammation by the nervous system.

UI	MeSH Term	Description	Entries
D007113	Immunity, Innate	The capacity of a normal organism to remain unaffected by microorganisms and their toxins. It results from the presence of naturally occurring ANTI-INFECTIVE AGENTS, constitutional factors such as BODY TEMPERATURE and immediate acting immune cells such as NATURAL KILLER CELLS.	Immunity, Native,Immunity, Natural,Immunity, Non-Specific,Resistance, Natural,Innate Immune Response,Innate Immunity,Immune Response, Innate,Immune Responses, Innate,Immunity, Non Specific,Innate Immune Responses,Native Immunity,Natural Immunity,Natural Resistance,Non-Specific Immunity
D007249	Inflammation	A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.	Innate Inflammatory Response,Inflammations,Inflammatory Response, Innate,Innate Inflammatory Responses
D008214	Lymphocytes	White blood cells formed in the body's lymphoid tissue. The nucleus is round or ovoid with coarse, irregularly clumped chromatin while the cytoplasm is typically pale blue with azurophilic (if any) granules. Most lymphocytes can be classified as either T or B (with subpopulations of each), or NATURAL KILLER CELLS.	Lymphoid Cells,Cell, Lymphoid,Cells, Lymphoid,Lymphocyte,Lymphoid Cell
D009474	Neurons	The basic cellular units of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the NERVOUS SYSTEM.	Nerve Cells,Cell, Nerve,Cells, Nerve,Nerve Cell,Neuron
D009479	Neuropeptides	Peptides released by NEURONS as intercellular messengers. Many neuropeptides are also hormones released by non-neuronal cells.	Neuropeptide
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D015213	Neuroimmunomodulation	The biochemical and electrophysiological interactions between the NERVOUS SYSTEM and IMMUNE SYSTEM.	Cholinergic Anti-inflammatory Pathway,Neuro-immune Axis,Neuro-immune Communication,Neuro-immune Interactions,Neuro-immunomodulation,Neuroimmune Axis,Neuroimmune Communication,Neuroimmune Interactions,Neuroimmune Processes,Vagal Anti-inflammatory Pathway,Vagal-immune Interactions,Neuroimmune Mechanisms,Neuroimmune Process,Anti-inflammatory Pathway, Cholinergic,Anti-inflammatory Pathway, Vagal,Cholinergic Anti inflammatory Pathway,Cholinergic Anti-inflammatory Pathways,Communication, Neuro-immune,Communication, Neuroimmune,Interaction, Neuro-immune,Interaction, Neuroimmune,Mechanism, Neuroimmune,Neuro immune Axis,Neuro immune Communication,Neuro immune Interactions,Neuro immunomodulation,Neuro-immune Communications,Neuro-immune Interaction,Neuroimmune Communications,Neuroimmune Interaction,Neuroimmune Mechanism,Process, Neuroimmune,Vagal Anti inflammatory Pathway,Vagal Anti-inflammatory Pathways,Vagal immune Interactions,Vagal-immune Interaction
D016207	Cytokines	Non-antibody proteins secreted by inflammatory leukocytes and some non-leukocytic cells, that act as intercellular mediators. They differ from classical hormones in that they are produced by a number of tissue or cell types rather than by specialized glands. They generally act locally in a paracrine or autocrine rather than endocrine manner.	Cytokine
D017154	Stromal Cells	Connective tissue cells of an organ found in the loose connective tissue. These are most often associated with the uterine mucosa and the ovary as well as the hematopoietic system and elsewhere.	Cell, Stromal,Cells, Stromal,Stromal Cell