Effects of sulfotanshinone sodium injection on the pharmacokinetics and pharmacodynamics of warfarin in rats in vivo. 2020

Yuan Shi, and Wenlong Zhang, and Meiting Jiang, and Lijun Huang, and Yangxu Zhou, and Jiayu Chen, and Duo Liu, and Gaofeng Liu, and Mei Dong
Department of Pharmacy, The Second Affiliated Hospital, Harbin Medical University, Harbin, China.

This study was to explore the effects of sulfotanshinone sodium injection (SSI) on the pharmacokinetics and pharmacodynamics of warfarin in rats.The studies of single dose and multiple dose of warfarin were designed to assess the interaction between warfarin and SSI. Rats were divided into different groups randomly and administered with warfarin in the absence or presence of SSI. Prothrombin time (PT) and activated partial thromboplastin time (APTT) values were detected by blood coagulation analyzer, and international normalized ratio (INR) values were calculated. Plasma concentrations of warfarin enantiomers were determined by UPLC-MS/MS method, pharmacokinetic parameters were calculated.The single-dose study demonstrated that the repeated doses of SSI alone had no effect on PT, APTT and INR values, but had a significant effect on PT and INR values produced by a single dose of warfarin, APTT values were unaffected. The Cmax, AUC of R-warfarin and S-warfarin were reduced, t1/2 were shortened. The multiple-dose study showed that PT, APTT, INR values, and the Cmax and AUC of R-warfarin and S-warfarin decreased significantly after administration of SSI.The finding implied that SSI could accelerate warfarin metabolism and weaken its anticoagulation. However, human SSI-warfarin interaction studies need to be conducted to confirm this finding.

UI MeSH Term Description Entries
D008297 Male Males
D010314 Partial Thromboplastin Time The time required for the appearance of FIBRIN strands following the mixing of PLASMA with phospholipid platelet substitute (e.g., crude cephalins, soybean phosphatides). It is a test of the intrinsic pathway (factors VIII, IX, XI, and XII) and the common pathway (fibrinogen, prothrombin, factors V and X) of BLOOD COAGULATION. It is used as a screening test and to monitor HEPARIN therapy. Activated Partial Thromboplastin Time,Cephalin-Kaolin Coagulation Time,Kaolin-Cephalin Coagulation Time,Thromboplastin Time, Partial,Coagulation Time, Cephalin-Kaolin,Cephalin Kaolin Coagulation Time,Coagulation Time, Cephalin Kaolin,Coagulation Time, Kaolin-Cephalin,Kaolin Cephalin Coagulation Time
D011517 Prothrombin Time Clotting time of PLASMA recalcified in the presence of excess TISSUE THROMBOPLASTIN. Factors measured are FIBRINOGEN; PROTHROMBIN; FACTOR V; FACTOR VII; and FACTOR X. It is used for monitoring anticoagulant therapy with COUMARINS. Quick Test,Russell's Viper Venom Time,Thrombotest,Russell Viper Venom Time,Russells Viper Venom Time,Prothrombin Times,Test, Quick,Time, Prothrombin,Times, Prothrombin
D002853 Chromatography, Liquid Chromatographic techniques in which the mobile phase is a liquid. Liquid Chromatography
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D014859 Warfarin An anticoagulant that acts by inhibiting the synthesis of vitamin K-dependent coagulation factors. Warfarin is indicated for the prophylaxis and/or treatment of venous thrombosis and its extension, pulmonary embolism, and atrial fibrillation with embolization. It is also used as an adjunct in the prophylaxis of systemic embolism after myocardial infarction. Warfarin is also used as a rodenticide. 4-Hydroxy-3-(3-oxo-1-phenylbutyl)-2H-1-benzopyran-2-one,Aldocumar,Apo-Warfarin,Coumadin,Coumadine,Gen-Warfarin,Marevan,Tedicumar,Warfant,Warfarin Potassium,Warfarin Sodium,Potassium, Warfarin,Sodium, Warfarin
D045784 Abietanes A subclass of cyclical DITERPENES that contain the abietane ring structure. Abietane Diterpene,Abietane Diterpenoid,Abietane Diterpenoids,Diterpenes, Abietane,Isopimarane,Isopimaranes,Totarane Diterpene,Totarane Diterpenes,Totaranes,Diterpenes, Pimarane,Pimaranes,Abietane Diterpenes,Diterpene, Abietane,Diterpene, Totarane,Diterpenoid, Abietane,Pimarane Diterpenes
D051381 Rats The common name for the genus Rattus. Rattus,Rats, Laboratory,Rats, Norway,Rattus norvegicus,Laboratory Rat,Laboratory Rats,Norway Rat,Norway Rats,Rat,Rat, Laboratory,Rat, Norway,norvegicus, Rattus
D053719 Tandem Mass Spectrometry A mass spectrometry technique using two (MS/MS) or more mass analyzers. With two in tandem, the precursor ions are mass-selected by a first mass analyzer, and focused into a collision region where they are then fragmented into product ions which are then characterized by a second mass analyzer. A variety of techniques are used to separate the compounds, ionize them, and introduce them to the first mass analyzer. For example, for in GC-MS/MS, GAS CHROMATOGRAPHY-MASS SPECTROMETRY is involved in separating relatively small compounds by GAS CHROMATOGRAPHY prior to injecting them into an ionization chamber for the mass selection. Mass Spectrometry-Mass Spectrometry,Mass Spectrometry Mass Spectrometry,Mass Spectrometry, Tandem

Related Publications

Yuan Shi, and Wenlong Zhang, and Meiting Jiang, and Lijun Huang, and Yangxu Zhou, and Jiayu Chen, and Duo Liu, and Gaofeng Liu, and Mei Dong
October 2020, Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica,
Yuan Shi, and Wenlong Zhang, and Meiting Jiang, and Lijun Huang, and Yangxu Zhou, and Jiayu Chen, and Duo Liu, and Gaofeng Liu, and Mei Dong
March 2021, Basic & clinical pharmacology & toxicology,
Yuan Shi, and Wenlong Zhang, and Meiting Jiang, and Lijun Huang, and Yangxu Zhou, and Jiayu Chen, and Duo Liu, and Gaofeng Liu, and Mei Dong
August 2018, Xenobiotica; the fate of foreign compounds in biological systems,
Yuan Shi, and Wenlong Zhang, and Meiting Jiang, and Lijun Huang, and Yangxu Zhou, and Jiayu Chen, and Duo Liu, and Gaofeng Liu, and Mei Dong
April 2013, British journal of pharmacology,
Yuan Shi, and Wenlong Zhang, and Meiting Jiang, and Lijun Huang, and Yangxu Zhou, and Jiayu Chen, and Duo Liu, and Gaofeng Liu, and Mei Dong
January 1999, The Journal of international medical research,
Yuan Shi, and Wenlong Zhang, and Meiting Jiang, and Lijun Huang, and Yangxu Zhou, and Jiayu Chen, and Duo Liu, and Gaofeng Liu, and Mei Dong
May 1995, The Journal of pharmacy and pharmacology,
Yuan Shi, and Wenlong Zhang, and Meiting Jiang, and Lijun Huang, and Yangxu Zhou, and Jiayu Chen, and Duo Liu, and Gaofeng Liu, and Mei Dong
August 2013, The Journal of pharmacy and pharmacology,
Yuan Shi, and Wenlong Zhang, and Meiting Jiang, and Lijun Huang, and Yangxu Zhou, and Jiayu Chen, and Duo Liu, and Gaofeng Liu, and Mei Dong
February 2024, BMC complementary medicine and therapies,
Yuan Shi, and Wenlong Zhang, and Meiting Jiang, and Lijun Huang, and Yangxu Zhou, and Jiayu Chen, and Duo Liu, and Gaofeng Liu, and Mei Dong
January 1992, European journal of drug metabolism and pharmacokinetics,
Yuan Shi, and Wenlong Zhang, and Meiting Jiang, and Lijun Huang, and Yangxu Zhou, and Jiayu Chen, and Duo Liu, and Gaofeng Liu, and Mei Dong
December 2019, Xenobiotica; the fate of foreign compounds in biological systems,
Copied contents to your clipboard!