BIOMAT Database Logo BIOMAT Database Logo

Histocompatibility antigens: markers of susceptibility to and protection from alcoholic liver disease in a Portuguese population. 1988

E Monteiro, and M P Alves, and M L Santos, and I Quintas, and A Baptista, and A Galvao-Teles, and J S Gavaler
Department of Medicine, Santa Maria University Hospital, Lisbon, Portugal.

The distribution of six HLA antigens in a population of 88 Portuguese chronic alcohol abusers with biopsy-proven liver disease was compared to that in 66 Portuguese normal controls. Among the group of 88 alcohol abusers, the presence of HLA antigens A1, A9, A28 and Bw35 marked a significant 2.5- to 3-fold increased estimated risk for the development of alcohol-induced cirrhosis, while the presence of HLA B5 was found to be associated with a significantly decreased risk of alcohol-induced cirrhosis. Further, compared to controls, the estimated risk of any stage of alcohol-induced liver disease was significantly increased in alcoholic individuals with HLA A28 and Bw35, and the protective effect of HLA B5 was again observed. The findings of this study suggest that at least in a relatively homogeneous population group such as the Portuguese, the presence of HLA B5 may confer protection against alcohol-induced liver disease, including cirrhosis. The presence of HLA Bw35 and A28 appear to mark susceptibility to all histologic manifestations of alcohol-induced liver disease, while in addition to Bw35 and A28, A1 and A9 may mark increased risk for cirrhosis in particular.

UI MeSH Term Description Entries
D008099 Liver A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances. Livers
D008104 Liver Cirrhosis, Alcoholic FIBROSIS of the hepatic parenchyma due to chronic excess ALCOHOL DRINKING. Alcoholic Cirrhosis,Hepatic Cirrhosis, Alcoholic,Alcoholic Hepatic Cirrhosis,Alcoholic Liver Cirrhosis
D008108 Liver Diseases, Alcoholic Liver diseases associated with ALCOHOLISM. It usually refers to the coexistence of two or more subentities, i.e., ALCOHOLIC FATTY LIVER; ALCOHOLIC HEPATITIS; and ALCOHOLIC CIRRHOSIS. Alcoholic Liver Diseases,Alcoholic Liver Disease,Liver Disease, Alcoholic
D008297 Male Males
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D011174 Portugal A country in southwestern Europe, bordering the North Atlantic Ocean, west of Spain. The capital is Lisbon. Madeira Island,Portuguese Republic
D004198 Disease Susceptibility A constitution or condition of the body which makes the tissues react in special ways to certain extrinsic stimuli and thus tends to make the individual more than usually susceptible to certain diseases. Diathesis,Susceptibility, Disease,Diatheses,Disease Susceptibilities,Susceptibilities, Disease
D005260 Female Females
D005819 Genetic Markers A phenotypically recognizable genetic trait which can be used to identify a genetic locus, a linkage group, or a recombination event. Chromosome Markers,DNA Markers,Markers, DNA,Markers, Genetic,Genetic Marker,Marker, Genetic,Chromosome Marker,DNA Marker,Marker, Chromosome,Marker, DNA,Markers, Chromosome
D006680 HLA Antigens Antigens determined by leukocyte loci found on chromosome 6, the major histocompatibility loci in humans. They are polypeptides or glycoproteins found on most nucleated cells and platelets, determine tissue types for transplantation, and are associated with certain diseases. Human Leukocyte Antigen,Human Leukocyte Antigens,Leukocyte Antigens,HL-A Antigens,Antigen, Human Leukocyte,Antigens, HL-A,Antigens, HLA,Antigens, Human Leukocyte,Antigens, Leukocyte,HL A Antigens,Leukocyte Antigen, Human,Leukocyte Antigens, Human

Related Publications

E Monteiro, and M P Alves, and M L Santos, and I Quintas, and A Baptista, and A Galvao-Teles, and J S Gavaler
Histocompatibility antigens in alcoholic liver disease.
January 1982, British medical bulletin,
E Monteiro, and M P Alves, and M L Santos, and I Quintas, and A Baptista, and A Galvao-Teles, and J S Gavaler
Histocompatibility antigens, autoantibodies, and immunoglobulins in alcoholic liver disease.
September 1976, British medical journal,
E Monteiro, and M P Alves, and M L Santos, and I Quintas, and A Baptista, and A Galvao-Teles, and J S Gavaler
Human histocompatibility antigens and susceptibility to disease.
October 1973, Science (New York, N.Y.),
E Monteiro, and M P Alves, and M L Santos, and I Quintas, and A Baptista, and A Galvao-Teles, and J S Gavaler
Distribution of HLA histocompatibility antigens, ABO blood groups and Rh antigens in alcoholic liver disease.
April 1979, Gut,
E Monteiro, and M P Alves, and M L Santos, and I Quintas, and A Baptista, and A Galvao-Teles, and J S Gavaler
Association of disease susceptibility to major histocompatibility antigens.
March 1979, Transplantation proceedings,
E Monteiro, and M P Alves, and M L Santos, and I Quintas, and A Baptista, and A Galvao-Teles, and J S Gavaler
Associations between major histocompatibility antigens and susceptibility to disease.
January 1979, Annual review of microbiology,
E Monteiro, and M P Alves, and M L Santos, and I Quintas, and A Baptista, and A Galvao-Teles, and J S Gavaler
HLA antigens as immunogenetic markers of alcoholism and alcoholic liver disease.
January 1980, Pharmacology, biochemistry, and behavior,
E Monteiro, and M P Alves, and M L Santos, and I Quintas, and A Baptista, and A Galvao-Teles, and J S Gavaler
[Class I histocompatibility antigens as markers of human susceptibility to influenza A viruses].
January 1995, Vestnik Rossiiskoi akademii meditsinskikh nauk,
E Monteiro, and M P Alves, and M L Santos, and I Quintas, and A Baptista, and A Galvao-Teles, and J S Gavaler
Histocompatibility antigens and alcoholic cardiomyopathy.
April 1980, Tissue antigens,
E Monteiro, and M P Alves, and M L Santos, and I Quintas, and A Baptista, and A Galvao-Teles, and J S Gavaler
Histocompatibility antigens in chronic liver disease.
January 1977, Gastroenterology,
Copied contents to your clipboard!