BIOMAT Database Logo BIOMAT Database Logo

Cytotoxic drug penetration studies in multicellular tumour spheroids. 1988

D J Kerr, and T E Wheldon, and S Hydns, and S B Kaye
Department of Medical Oncology, University of Glasgow, UK.

1. The three-dimensional structure of human lung tumour spheroids conferred a degree of resistance to the anthracyclines adriamycin, 4'-deoxydoxorubicin, daunomycin and daunomycin-low density lipoprotein complex in comparison with cells grown as a monolayer, as assessed by delayed growth and clonogenic cell survival. 2. 4'-Deoxydoxorubicin induced a longer growth delay and greater clonogenic cell kill than adriamycin in spheroids, although it was no more cytotoxic in monolayer. 3. Fluorescent microscopy demonstrated that the more lipophilic analogues partitioned into the spheroid more rapidly and to a greater degree than adriamycin. 4. The spheroid model demonstrated that penetration is an important aspect of resistance to anthracycline drugs, and this approach may represent a better in vitro system for testing lipophilic analogues of cytotoxic drugs.

UI MeSH Term Description Entries
D007700 Kinetics The rate dynamics in chemical or physical systems.
D008175 Lung Neoplasms Tumors or cancer of the LUNG. Cancer of Lung,Lung Cancer,Pulmonary Cancer,Pulmonary Neoplasms,Cancer of the Lung,Neoplasms, Lung,Neoplasms, Pulmonary,Cancer, Lung,Cancer, Pulmonary,Cancers, Lung,Cancers, Pulmonary,Lung Cancers,Lung Neoplasm,Neoplasm, Lung,Neoplasm, Pulmonary,Pulmonary Cancers,Pulmonary Neoplasm
D009279 Naphthacenes Polyacenes with four ortho-fused benzene rings in a straight linear arrangement. This group is best known for the subclass called TETRACYCLINES. Tetracenes,Benz(b)Anthracenes
D002449 Cell Aggregation The phenomenon by which dissociated cells intermixed in vitro tend to group themselves with cells of their own type. Aggregation, Cell,Aggregations, Cell,Cell Aggregations
D002455 Cell Division The fission of a CELL. It includes CYTOKINESIS, when the CYTOPLASM of a cell is divided, and CELL NUCLEUS DIVISION. M Phase,Cell Division Phase,Cell Divisions,Division Phase, Cell,Division, Cell,Divisions, Cell,M Phases,Phase, Cell Division,Phase, M,Phases, M
D002460 Cell Line Established cell cultures that have the potential to propagate indefinitely. Cell Lines,Line, Cell,Lines, Cell
D002470 Cell Survival The span of viability of a cell characterized by the capacity to perform certain functions such as metabolism, growth, reproduction, some form of responsiveness, and adaptability. Cell Viability,Cell Viabilities,Survival, Cell,Viabilities, Cell,Viability, Cell
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000903 Antibiotics, Antineoplastic Chemical substances, produced by microorganisms, inhibiting or preventing the proliferation of neoplasms. Antineoplastic Antibiotics,Cytotoxic Antibiotics,Antibiotics, Cytotoxic
D014407 Tumor Cells, Cultured Cells grown in vitro from neoplastic tissue. If they can be established as a TUMOR CELL LINE, they can be propagated in cell culture indefinitely. Cultured Tumor Cells,Neoplastic Cells, Cultured,Cultured Neoplastic Cells,Cell, Cultured Neoplastic,Cell, Cultured Tumor,Cells, Cultured Neoplastic,Cells, Cultured Tumor,Cultured Neoplastic Cell,Cultured Tumor Cell,Neoplastic Cell, Cultured,Tumor Cell, Cultured

Related Publications

D J Kerr, and T E Wheldon, and S Hydns, and S B Kaye
In vitro cytotoxic drug sensitivity testing of human tumour xenografts grown as multicellular tumour spheroids.
December 1982, British journal of cancer,
D J Kerr, and T E Wheldon, and S Hydns, and S B Kaye
Response of EMT6 multicellular tumour spheroids to hyperthermia and cytotoxic drugs.
March 1981, British journal of cancer,
D J Kerr, and T E Wheldon, and S Hydns, and S B Kaye
Unsuccessful mitosis in multicellular tumour spheroids.
April 2017, Oncotarget,
D J Kerr, and T E Wheldon, and S Hydns, and S B Kaye
Multicellular tumour spheroids in radiation biology.
July 1999, International journal of radiation biology,
D J Kerr, and T E Wheldon, and S Hydns, and S B Kaye
Increased nanoparticle penetration in collagenase-treated multicellular spheroids.
January 2007, International journal of nanomedicine,
D J Kerr, and T E Wheldon, and S Hydns, and S B Kaye
Chemical analysis of multicellular tumour spheroids.
June 2015, The Analyst,
D J Kerr, and T E Wheldon, and S Hydns, and S B Kaye
Optical properties of multicellular tumour spheroids.
June 1996, Physics in medicine and biology,
D J Kerr, and T E Wheldon, and S Hydns, and S B Kaye
Penetration and drug delivery of albumin nanoparticles into pancreatic multicellular tumor spheroids.
December 2017, Journal of materials chemistry. B,
D J Kerr, and T E Wheldon, and S Hydns, and S B Kaye
Mathematical Modeling of Bacteria-Enabled Drug Delivery System Penetration into Multicellular Tumor Spheroids.
July 2018, Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference,
D J Kerr, and T E Wheldon, and S Hydns, and S B Kaye
Oscillating growth patterns of multicellular tumour spheroids.
February 1999, Cell proliferation,
Copied contents to your clipboard!