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Cisplatin and 5-fluorouracil in refractory breast cancer patients: a phase II study. 1988
D Amoroso, and
P Pronzato, and
G Bertelli, and
P Gallotti, and
G Pastorino, and
M P Cusimano, and
M Merlano, and
P F Conte, and
R Rosso
Istituto Nazionale per la Ricerca sul Cancro, Divisione di Oncologia Medica, Genova, Italy.
24 patients with a median of 3 prior chemotherapy regimens were treated in our department with cisplatin 20 mg/m2 (with pre- and posthydration) and 5-fluorouracil 200 mg/m2 i.v. on day 1-5, every three weeks. 23 patients are evaluable; one had early death. 4 patients (17%) achieved a partial response, 8 had stable disease, and 11 progressed. Toxicity observed was moderate and no renal toxicity was noted. This study therefore shows tolerable toxicity but limited usefulness of adding cisplatin to 5-fluorouracil according to this schedule in these highly pretreated patients.
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