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The 125I-C1q binding test for the detection of soluble immune complexes in native unheated human serum was applied to the study of sera from 52 patients with diabetes mellitus in childhood. This radiolabeled C1q binding test is more sensitive and reproducible among the various methods proposed for the detection of immune complexes. The 125I-C1q binding activity in 52 sera from diabetes mellitus in childhood was 9.47 +/- 0.36% compared to 6.94 +/- 0.74% in normal controls. 125I-C1q binding values in diabetes mellitus in childhood were significantly higher than normal controls. Slight high values were seen in 3 patients with positive anti-DNA-antibodies in diabetes mellitus in childhood. 125I-C1q binding was not significantly increased in patients with positive antithyroid antibodies and insulin antibodies. There was no significant correlation between the duration of diabetes and 125I-C1q binding activity.
K Nagaoka, and
Y Chinen, and
T Takegami, and
N Nabeya, and
T Sakurami, and
H Imura, and
S Kuno, and
K Tasaka, and
Y Hamajima
March 1979,
The Journal of clinical investigation,
K Nagaoka, and
Y Chinen, and
T Takegami, and
N Nabeya, and
T Sakurami, and
H Imura, and
S Kuno, and
K Tasaka, and
Y Hamajima
February 1979,
The Journal of laboratory and clinical medicine,
K Nagaoka, and
Y Chinen, and
T Takegami, and
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H Imura, and
S Kuno, and
K Tasaka, and
Y Hamajima
December 1977,
Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete,
K Nagaoka, and
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T Takegami, and
N Nabeya, and
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January 1988,
Clinical immunology and immunopathology,
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January 1981,
Methods in enzymology,
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October 1981,
Pediatriia,
K Nagaoka, and
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H Imura, and
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January 1981,
Methods in enzymology,
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N Nabeya, and
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H Imura, and
S Kuno, and
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Y Hamajima
January 1984,
Proceedings of the National Science Council, Republic of China. Part B, Life sciences,
K Nagaoka, and
Y Chinen, and
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K Tasaka, and
Y Hamajima
January 1982,
Immunobiology,
K Nagaoka, and
Y Chinen, and
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N Nabeya, and
T Sakurami, and
H Imura, and
S Kuno, and
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January 1986,
International archives of allergy and applied immunology,
