-transparent.png){kind=logo}
From 97 children with bacteriologically confirmed Haemophilus influenzae meningitis, 39 were treated with chloramphenicol (before 1970) and 58 with ampicillin (since 1970). In 1977 all patients were followed up with history, clinical examination, and audiometry. Sensorineural hearing defect was found in 5 chloramphenicol patients and in 10 ampicillin patients. Of the 82 patients for whom treatment was begun within 48 h of onset of symptoms, only two showed hearing deficit, while 13 of the 15 patients in whom treatment was begun later suffered from hearing impairment. It appears that it is not the antibiotic, but the delay between onset of symptoms and start of therapy, that is decisive for the occurrence of inner ear impairment.
B Richner, and
E Hof, and
A Prader
August 1985,
International journal of pediatric otorhinolaryngology,
B Richner, and
E Hof, and
A Prader
July 1979,
International journal of pediatric otorhinolaryngology,
B Richner, and
E Hof, and
A Prader
June 1992,
Clinical pediatrics,
B Richner, and
E Hof, and
A Prader
September 1972,
The New England journal of medicine,
B Richner, and
E Hof, and
A Prader
January 1984,
Pediatric infectious disease,
B Richner, and
E Hof, and
A Prader
August 1948,
Revista cubana de pediatria,
B Richner, and
E Hof, and
A Prader
January 1999,
Ryoikibetsu shokogun shirizu,
B Richner, and
E Hof, and
A Prader
March 1976,
The Journal of antimicrobial chemotherapy,
B Richner, and
E Hof, and
A Prader
January 1976,
Ugeskrift for laeger,
B Richner, and
E Hof, and
A Prader
April 1996,
Archives de pediatrie : organe officiel de la Societe francaise de pediatrie,
