-transparent.png){kind=logo}
C4 nephritic factor in patients with immune-complex-mediated membranoproliferative glomerulonephritis and C3-glomerulopathy. 2019
Nóra Garam, and
Zoltán Prohászka, and
Ágnes Szilágyi, and
Christof Aigner, and
Alice Schmidt, and
Martina Gaggl, and
Gere Sunder-Plassmann, and
Dóra Bajcsi, and
Jürgen Brunner, and
Alexandra Dumfarth, and
Daniel Cejka, and
Stefan Flaschberger, and
Hana Flögelova, and
Ágnes Haris, and
Ágnes Hartmann, and
Andreas Heilos, and
Thomas Mueller, and
Krisztina Rusai, and
Klaus Arbeiter, and
Johannes Hofer, and
Dániel Jakab, and
Mária Sinkó, and
Erika Szigeti, and
Csaba Bereczki, and
Viktor Janko, and
Kata Kelen, and
György S Reusz, and
Attila J Szabó, and
Nóra Klenk, and
Krisztina Kóbor, and
Nika Kojc, and
Maarten Knechtelsdorfer, and
Mario Laganovic, and
Adrian Catalin Lungu, and
Anamarija Meglic, and
Rina Rus, and
Tanja Kersnik-Levart, and
Ernesta Macioniene, and
Marius Miglinas, and
Anna Pawłowska, and
Tomasz Stompór, and
Ludmila Podracka, and
Michael Rudnicki, and
Gert Mayer, and
Romana Rysava, and
Jana Reiterova, and
Marijan Saraga, and
Tomáš Seeman, and
Jakub Zieg, and
Eva Sládková, and
Tamás Szabó, and
Andrei Capitanescu, and
Simona Stancu, and
Miroslav Tisljar, and
Kresimir Galesic, and
András Tislér, and
Inga Vainumäe, and
Martin Windpessl, and
Tomas Zaoral, and
Galia Zlatanova, and
Dorottya Csuka
Research Laboratory, 3rd Department of Internal Medicine, and MTA-SE Research Group of Immunology and Hematology, Hungarian Academy of Sciences and Semmelweis University, Kútvölgyi St 4, Budapest, H-1125, Hungary.
Acquired or genetic abnormalities of the complement alternative pathway are the primary cause of C3glomerulopathy(C3G) but may occur in immune-complex-mediated membranoproliferative glomerulonephritis (IC-MPGN) as well. Less is known about the presence and role of C4nephritic factor(C4NeF) which may stabilize the classical pathway C3-convertase. Our aim was to examine the presence of C4NeF and its connection with clinical features and with other pathogenic factors. One hunfe IC-MPGN/C3G patients were enrolled in the study. C4NeF activity was determined by hemolytic assay utilizing sensitized sheep erythrocytes. Seventeen patients were positive for C4NeF with lower prevalence of renal impairment and lower C4d level, and higher C3 nephritic factor (C3NeF) prevalence at time of diagnosis compared to C4NeF negative patients. Patients positive for both C3NeF and C4NeF had the lowest C3 levels and highest terminal pathway activation. End-stage renal disease did not develop in any of the C4NeF positive patients during follow-up period. Positivity to other complement autoantibodies (anti-C1q, anti-C3) was also linked to the presence of nephritic factors. Unsupervised, data-driven cluster analysis identified a group of patients with high prevalence of multiple complement autoantibodies, including C4NeF. In conclusion, C4NeF may be a possible cause of complement dysregulation in approximately 10-15% of IC-MPGN/C3G patients.
Related Publications
Nóra Garam, and
Zoltán Prohászka, and
Ágnes Szilágyi, and
Christof Aigner, and
Alice Schmidt, and
Martina Gaggl, and
Gere Sunder-Plassmann, and
Dóra Bajcsi, and
Jürgen Brunner, and
Alexandra Dumfarth, and
Daniel Cejka, and
Stefan Flaschberger, and
Hana Flögelova, and
Ágnes Haris, and
Ágnes Hartmann, and
Andreas Heilos, and
Thomas Mueller, and
Krisztina Rusai, and
Klaus Arbeiter, and
Johannes Hofer, and
Dániel Jakab, and
Mária Sinkó, and
Erika Szigeti, and
Csaba Bereczki, and
Viktor Janko, and
Kata Kelen, and
György S Reusz, and
Attila J Szabó, and
Nóra Klenk, and
Krisztina Kóbor, and
Nika Kojc, and
Maarten Knechtelsdorfer, and
Mario Laganovic, and
Adrian Catalin Lungu, and
Anamarija Meglic, and
Rina Rus, and
Tanja Kersnik-Levart, and
Ernesta Macioniene, and
Marius Miglinas, and
Anna Pawłowska, and
Tomasz Stompór, and
Ludmila Podracka, and
Michael Rudnicki, and
Gert Mayer, and
Romana Rysava, and
Jana Reiterova, and
Marijan Saraga, and
Tomáš Seeman, and
Jakub Zieg, and
Eva Sládková, and
Tamás Szabó, and
Andrei Capitanescu, and
Simona Stancu, and
Miroslav Tisljar, and
Kresimir Galesic, and
András Tislér, and
Inga Vainumäe, and
Martin Windpessl, and
Tomas Zaoral, and
Galia Zlatanova, and
Dorottya Csuka
February 1994,
Clinical and experimental immunology,
Nóra Garam, and
Zoltán Prohászka, and
Ágnes Szilágyi, and
Christof Aigner, and
Alice Schmidt, and
Martina Gaggl, and
Gere Sunder-Plassmann, and
Dóra Bajcsi, and
Jürgen Brunner, and
Alexandra Dumfarth, and
Daniel Cejka, and
Stefan Flaschberger, and
Hana Flögelova, and
Ágnes Haris, and
Ágnes Hartmann, and
Andreas Heilos, and
Thomas Mueller, and
Krisztina Rusai, and
Klaus Arbeiter, and
Johannes Hofer, and
Dániel Jakab, and
Mária Sinkó, and
Erika Szigeti, and
Csaba Bereczki, and
Viktor Janko, and
Kata Kelen, and
György S Reusz, and
Attila J Szabó, and
Nóra Klenk, and
Krisztina Kóbor, and
Nika Kojc, and
Maarten Knechtelsdorfer, and
Mario Laganovic, and
Adrian Catalin Lungu, and
Anamarija Meglic, and
Rina Rus, and
Tanja Kersnik-Levart, and
Ernesta Macioniene, and
Marius Miglinas, and
Anna Pawłowska, and
Tomasz Stompór, and
Ludmila Podracka, and
Michael Rudnicki, and
Gert Mayer, and
Romana Rysava, and
Jana Reiterova, and
Marijan Saraga, and
Tomáš Seeman, and
Jakub Zieg, and
Eva Sládková, and
Tamás Szabó, and
Andrei Capitanescu, and
Simona Stancu, and
Miroslav Tisljar, and
Kresimir Galesic, and
András Tislér, and
Inga Vainumäe, and
Martin Windpessl, and
Tomas Zaoral, and
Galia Zlatanova, and
Dorottya Csuka
April 1989,
Clinical and experimental immunology,
Nóra Garam, and
Zoltán Prohászka, and
Ágnes Szilágyi, and
Christof Aigner, and
Alice Schmidt, and
Martina Gaggl, and
Gere Sunder-Plassmann, and
Dóra Bajcsi, and
Jürgen Brunner, and
Alexandra Dumfarth, and
Daniel Cejka, and
Stefan Flaschberger, and
Hana Flögelova, and
Ágnes Haris, and
Ágnes Hartmann, and
Andreas Heilos, and
Thomas Mueller, and
Krisztina Rusai, and
Klaus Arbeiter, and
Johannes Hofer, and
Dániel Jakab, and
Mária Sinkó, and
Erika Szigeti, and
Csaba Bereczki, and
Viktor Janko, and
Kata Kelen, and
György S Reusz, and
Attila J Szabó, and
Nóra Klenk, and
Krisztina Kóbor, and
Nika Kojc, and
Maarten Knechtelsdorfer, and
Mario Laganovic, and
Adrian Catalin Lungu, and
Anamarija Meglic, and
Rina Rus, and
Tanja Kersnik-Levart, and
Ernesta Macioniene, and
Marius Miglinas, and
Anna Pawłowska, and
Tomasz Stompór, and
Ludmila Podracka, and
Michael Rudnicki, and
Gert Mayer, and
Romana Rysava, and
Jana Reiterova, and
Marijan Saraga, and
Tomáš Seeman, and
Jakub Zieg, and
Eva Sládková, and
Tamás Szabó, and
Andrei Capitanescu, and
Simona Stancu, and
Miroslav Tisljar, and
Kresimir Galesic, and
András Tislér, and
Inga Vainumäe, and
Martin Windpessl, and
Tomas Zaoral, and
Galia Zlatanova, and
Dorottya Csuka
January 1987,
Nephron,
Nóra Garam, and
Zoltán Prohászka, and
Ágnes Szilágyi, and
Christof Aigner, and
Alice Schmidt, and
Martina Gaggl, and
Gere Sunder-Plassmann, and
Dóra Bajcsi, and
Jürgen Brunner, and
Alexandra Dumfarth, and
Daniel Cejka, and
Stefan Flaschberger, and
Hana Flögelova, and
Ágnes Haris, and
Ágnes Hartmann, and
Andreas Heilos, and
Thomas Mueller, and
Krisztina Rusai, and
Klaus Arbeiter, and
Johannes Hofer, and
Dániel Jakab, and
Mária Sinkó, and
Erika Szigeti, and
Csaba Bereczki, and
Viktor Janko, and
Kata Kelen, and
György S Reusz, and
Attila J Szabó, and
Nóra Klenk, and
Krisztina Kóbor, and
Nika Kojc, and
Maarten Knechtelsdorfer, and
Mario Laganovic, and
Adrian Catalin Lungu, and
Anamarija Meglic, and
Rina Rus, and
Tanja Kersnik-Levart, and
Ernesta Macioniene, and
Marius Miglinas, and
Anna Pawłowska, and
Tomasz Stompór, and
Ludmila Podracka, and
Michael Rudnicki, and
Gert Mayer, and
Romana Rysava, and
Jana Reiterova, and
Marijan Saraga, and
Tomáš Seeman, and
Jakub Zieg, and
Eva Sládková, and
Tamás Szabó, and
Andrei Capitanescu, and
Simona Stancu, and
Miroslav Tisljar, and
Kresimir Galesic, and
András Tislér, and
Inga Vainumäe, and
Martin Windpessl, and
Tomas Zaoral, and
Galia Zlatanova, and
Dorottya Csuka
February 2023,
Cells,
Nóra Garam, and
Zoltán Prohászka, and
Ágnes Szilágyi, and
Christof Aigner, and
Alice Schmidt, and
Martina Gaggl, and
Gere Sunder-Plassmann, and
Dóra Bajcsi, and
Jürgen Brunner, and
Alexandra Dumfarth, and
Daniel Cejka, and
Stefan Flaschberger, and
Hana Flögelova, and
Ágnes Haris, and
Ágnes Hartmann, and
Andreas Heilos, and
Thomas Mueller, and
Krisztina Rusai, and
Klaus Arbeiter, and
Johannes Hofer, and
Dániel Jakab, and
Mária Sinkó, and
Erika Szigeti, and
Csaba Bereczki, and
Viktor Janko, and
Kata Kelen, and
György S Reusz, and
Attila J Szabó, and
Nóra Klenk, and
Krisztina Kóbor, and
Nika Kojc, and
Maarten Knechtelsdorfer, and
Mario Laganovic, and
Adrian Catalin Lungu, and
Anamarija Meglic, and
Rina Rus, and
Tanja Kersnik-Levart, and
Ernesta Macioniene, and
Marius Miglinas, and
Anna Pawłowska, and
Tomasz Stompór, and
Ludmila Podracka, and
Michael Rudnicki, and
Gert Mayer, and
Romana Rysava, and
Jana Reiterova, and
Marijan Saraga, and
Tomáš Seeman, and
Jakub Zieg, and
Eva Sládková, and
Tamás Szabó, and
Andrei Capitanescu, and
Simona Stancu, and
Miroslav Tisljar, and
Kresimir Galesic, and
András Tislér, and
Inga Vainumäe, and
Martin Windpessl, and
Tomas Zaoral, and
Galia Zlatanova, and
Dorottya Csuka
January 2021,
Frontiers in immunology,
Nóra Garam, and
Zoltán Prohászka, and
Ágnes Szilágyi, and
Christof Aigner, and
Alice Schmidt, and
Martina Gaggl, and
Gere Sunder-Plassmann, and
Dóra Bajcsi, and
Jürgen Brunner, and
Alexandra Dumfarth, and
Daniel Cejka, and
Stefan Flaschberger, and
Hana Flögelova, and
Ágnes Haris, and
Ágnes Hartmann, and
Andreas Heilos, and
Thomas Mueller, and
Krisztina Rusai, and
Klaus Arbeiter, and
Johannes Hofer, and
Dániel Jakab, and
Mária Sinkó, and
Erika Szigeti, and
Csaba Bereczki, and
Viktor Janko, and
Kata Kelen, and
György S Reusz, and
Attila J Szabó, and
Nóra Klenk, and
Krisztina Kóbor, and
Nika Kojc, and
Maarten Knechtelsdorfer, and
Mario Laganovic, and
Adrian Catalin Lungu, and
Anamarija Meglic, and
Rina Rus, and
Tanja Kersnik-Levart, and
Ernesta Macioniene, and
Marius Miglinas, and
Anna Pawłowska, and
Tomasz Stompór, and
Ludmila Podracka, and
Michael Rudnicki, and
Gert Mayer, and
Romana Rysava, and
Jana Reiterova, and
Marijan Saraga, and
Tomáš Seeman, and
Jakub Zieg, and
Eva Sládková, and
Tamás Szabó, and
Andrei Capitanescu, and
Simona Stancu, and
Miroslav Tisljar, and
Kresimir Galesic, and
András Tislér, and
Inga Vainumäe, and
Martin Windpessl, and
Tomas Zaoral, and
Galia Zlatanova, and
Dorottya Csuka
March 2021,
Pediatric nephrology (Berlin, Germany),
Nóra Garam, and
Zoltán Prohászka, and
Ágnes Szilágyi, and
Christof Aigner, and
Alice Schmidt, and
Martina Gaggl, and
Gere Sunder-Plassmann, and
Dóra Bajcsi, and
Jürgen Brunner, and
Alexandra Dumfarth, and
Daniel Cejka, and
Stefan Flaschberger, and
Hana Flögelova, and
Ágnes Haris, and
Ágnes Hartmann, and
Andreas Heilos, and
Thomas Mueller, and
Krisztina Rusai, and
Klaus Arbeiter, and
Johannes Hofer, and
Dániel Jakab, and
Mária Sinkó, and
Erika Szigeti, and
Csaba Bereczki, and
Viktor Janko, and
Kata Kelen, and
György S Reusz, and
Attila J Szabó, and
Nóra Klenk, and
Krisztina Kóbor, and
Nika Kojc, and
Maarten Knechtelsdorfer, and
Mario Laganovic, and
Adrian Catalin Lungu, and
Anamarija Meglic, and
Rina Rus, and
Tanja Kersnik-Levart, and
Ernesta Macioniene, and
Marius Miglinas, and
Anna Pawłowska, and
Tomasz Stompór, and
Ludmila Podracka, and
Michael Rudnicki, and
Gert Mayer, and
Romana Rysava, and
Jana Reiterova, and
Marijan Saraga, and
Tomáš Seeman, and
Jakub Zieg, and
Eva Sládková, and
Tamás Szabó, and
Andrei Capitanescu, and
Simona Stancu, and
Miroslav Tisljar, and
Kresimir Galesic, and
András Tislér, and
Inga Vainumäe, and
Martin Windpessl, and
Tomas Zaoral, and
Galia Zlatanova, and
Dorottya Csuka
January 2021,
Frontiers in genetics,
Nóra Garam, and
Zoltán Prohászka, and
Ágnes Szilágyi, and
Christof Aigner, and
Alice Schmidt, and
Martina Gaggl, and
Gere Sunder-Plassmann, and
Dóra Bajcsi, and
Jürgen Brunner, and
Alexandra Dumfarth, and
Daniel Cejka, and
Stefan Flaschberger, and
Hana Flögelova, and
Ágnes Haris, and
Ágnes Hartmann, and
Andreas Heilos, and
Thomas Mueller, and
Krisztina Rusai, and
Klaus Arbeiter, and
Johannes Hofer, and
Dániel Jakab, and
Mária Sinkó, and
Erika Szigeti, and
Csaba Bereczki, and
Viktor Janko, and
Kata Kelen, and
György S Reusz, and
Attila J Szabó, and
Nóra Klenk, and
Krisztina Kóbor, and
Nika Kojc, and
Maarten Knechtelsdorfer, and
Mario Laganovic, and
Adrian Catalin Lungu, and
Anamarija Meglic, and
Rina Rus, and
Tanja Kersnik-Levart, and
Ernesta Macioniene, and
Marius Miglinas, and
Anna Pawłowska, and
Tomasz Stompór, and
Ludmila Podracka, and
Michael Rudnicki, and
Gert Mayer, and
Romana Rysava, and
Jana Reiterova, and
Marijan Saraga, and
Tomáš Seeman, and
Jakub Zieg, and
Eva Sládková, and
Tamás Szabó, and
Andrei Capitanescu, and
Simona Stancu, and
Miroslav Tisljar, and
Kresimir Galesic, and
András Tislér, and
Inga Vainumäe, and
Martin Windpessl, and
Tomas Zaoral, and
Galia Zlatanova, and
Dorottya Csuka
May 2019,
Der Internist,
Nóra Garam, and
Zoltán Prohászka, and
Ágnes Szilágyi, and
Christof Aigner, and
Alice Schmidt, and
Martina Gaggl, and
Gere Sunder-Plassmann, and
Dóra Bajcsi, and
Jürgen Brunner, and
Alexandra Dumfarth, and
Daniel Cejka, and
Stefan Flaschberger, and
Hana Flögelova, and
Ágnes Haris, and
Ágnes Hartmann, and
Andreas Heilos, and
Thomas Mueller, and
Krisztina Rusai, and
Klaus Arbeiter, and
Johannes Hofer, and
Dániel Jakab, and
Mária Sinkó, and
Erika Szigeti, and
Csaba Bereczki, and
Viktor Janko, and
Kata Kelen, and
György S Reusz, and
Attila J Szabó, and
Nóra Klenk, and
Krisztina Kóbor, and
Nika Kojc, and
Maarten Knechtelsdorfer, and
Mario Laganovic, and
Adrian Catalin Lungu, and
Anamarija Meglic, and
Rina Rus, and
Tanja Kersnik-Levart, and
Ernesta Macioniene, and
Marius Miglinas, and
Anna Pawłowska, and
Tomasz Stompór, and
Ludmila Podracka, and
Michael Rudnicki, and
Gert Mayer, and
Romana Rysava, and
Jana Reiterova, and
Marijan Saraga, and
Tomáš Seeman, and
Jakub Zieg, and
Eva Sládková, and
Tamás Szabó, and
Andrei Capitanescu, and
Simona Stancu, and
Miroslav Tisljar, and
Kresimir Galesic, and
András Tislér, and
Inga Vainumäe, and
Martin Windpessl, and
Tomas Zaoral, and
Galia Zlatanova, and
Dorottya Csuka
December 2020,
Kidney international reports,
Nóra Garam, and
Zoltán Prohászka, and
Ágnes Szilágyi, and
Christof Aigner, and
Alice Schmidt, and
Martina Gaggl, and
Gere Sunder-Plassmann, and
Dóra Bajcsi, and
Jürgen Brunner, and
Alexandra Dumfarth, and
Daniel Cejka, and
Stefan Flaschberger, and
Hana Flögelova, and
Ágnes Haris, and
Ágnes Hartmann, and
Andreas Heilos, and
Thomas Mueller, and
Krisztina Rusai, and
Klaus Arbeiter, and
Johannes Hofer, and
Dániel Jakab, and
Mária Sinkó, and
Erika Szigeti, and
Csaba Bereczki, and
Viktor Janko, and
Kata Kelen, and
György S Reusz, and
Attila J Szabó, and
Nóra Klenk, and
Krisztina Kóbor, and
Nika Kojc, and
Maarten Knechtelsdorfer, and
Mario Laganovic, and
Adrian Catalin Lungu, and
Anamarija Meglic, and
Rina Rus, and
Tanja Kersnik-Levart, and
Ernesta Macioniene, and
Marius Miglinas, and
Anna Pawłowska, and
Tomasz Stompór, and
Ludmila Podracka, and
Michael Rudnicki, and
Gert Mayer, and
Romana Rysava, and
Jana Reiterova, and
Marijan Saraga, and
Tomáš Seeman, and
Jakub Zieg, and
Eva Sládková, and
Tamás Szabó, and
Andrei Capitanescu, and
Simona Stancu, and
Miroslav Tisljar, and
Kresimir Galesic, and
András Tislér, and
Inga Vainumäe, and
Martin Windpessl, and
Tomas Zaoral, and
Galia Zlatanova, and
Dorottya Csuka
November 1982,
Clinical nephrology,
