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Iridium(iii) complexes of 1,2,4-triazines as potential bioorthogonal reagents: metal coordination facilitates luminogenic reaction with strained cyclooctynes. 2019

Valery N Kozhevnikov, and Michael E Deary, and Theodora Mantso, and Mihalis I Panayiotidis, and Mark T Sims
Department of Applied Sciences, Northumbria University, Newcastle upon Tyne, NE1 8ST, UK. valery.kozhevnikov@northumbria.ac.uk.

In this paper we describe unprecedented Ir(iii) complexes of 5-(2-pyridyl)-1,2,4-triazine and their reactivity towards the strained cyclooctyne BCN. The coordination of a 1,2,4-triazine ring to an iridium(iii) ion drastically increases the speed of the reaction, showing the second order rate constant of 8 M-1 s-1, the record value to date for a triazine-BCN reaction.

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