BIOMAT Database Logo BIOMAT Database Logo

Suppression of exercise-induced angina by magnesium sulfate in patients with variant angina. 1988

K Kugiyama, and H Yasue, and K Okumura, and K Goto, and K Minoda, and H Miyagi, and K Matsuyama, and A Kojima, and Y Koga, and M Takahashi
Department of Radiology, Kumamoto University Medical School, Japan.

The effects of intravenous magnesium on exercise-induced angina were examined in 15 patients with variant angina and in 13 patients with stable effort angina and were compared with those of placebo. Symptom-limited bicycle exercise and thallium-201 myocardial scintigraphy were performed after intravenous administration of 0.27 mmol/kg body weight of magnesium sulfate and after placebo on different days. In all patients, serum magnesium levels after administration of magnesium sulfate were about twofold higher than levels after placebo. Exercise-induced angina associated with transient ST segment elevation occurred in 11 patients with variant angina receiving placebo and in only 2 of these patients receiving magnesium (p less than 0.005). On the other hand, exercise-induced angina was not suppressed by magnesium in any patient with stable effort angina. In these patients there was no significant difference in exercise duration after administration of placebo versus after administration of magnesium. The size of the perfusion defect as measured by thallium-201 scintigraphy was significantly less in patients with variant angina receiving magnesium than that in those receiving placebo (p less than 0.001), whereas it was not significantly different in patients with stable effort angina receiving placebo versus magnesium. In conclusion, exercise-induced angina is suppressed by intravenous magnesium in patients with variant angina but not in patients with stable effort angina. This beneficial effect of magnesium in patients with variant angina is most likely due to improvement of regional myocardial blood flow by suppression of coronary artery spasm.

UI MeSH Term Description Entries
D007275 Injections, Intravenous Injections made into a vein for therapeutic or experimental purposes. Intravenous Injections,Injection, Intravenous,Intravenous Injection
D008278 Magnesium Sulfate A small colorless crystal used as an anticonvulsant, a cathartic, and an electrolyte replenisher in the treatment of pre-eclampsia and eclampsia. It causes direct inhibition of action potentials in myometrial muscle cells. Excitation and contraction are uncoupled, which decreases the frequency and force of contractions. (From AMA Drug Evaluations Annual, 1992, p1083) Magnesium Sulfate, Heptahydrate,Heptahydrate Magnesium Sulfate,Sulfate, Magnesium
D008297 Male Males
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D011877 Radionuclide Imaging The production of an image obtained by cameras that detect the radioactive emissions of an injected radionuclide as it has distributed differentially throughout tissues in the body. The image obtained from a moving detector is called a scan, while the image obtained from a stationary camera device is called a scintiphotograph. Gamma Camera Imaging,Radioisotope Scanning,Scanning, Radioisotope,Scintigraphy,Scintiphotography,Imaging, Gamma Camera,Imaging, Radionuclide
D005080 Exercise Test Controlled physical activity which is performed in order to allow assessment of physiological functions, particularly cardiovascular and pulmonary, but also aerobic capacity. Maximal (most intense) exercise is usually required but submaximal exercise is also used. Arm Ergometry Test,Bicycle Ergometry Test,Cardiopulmonary Exercise Testing,Exercise Testing,Step Test,Stress Test,Treadmill Test,Cardiopulmonary Exercise Test,EuroFit Tests,Eurofit Test Battery,European Fitness Testing Battery,Fitness Testing,Physical Fitness Testing,Arm Ergometry Tests,Bicycle Ergometry Tests,Cardiopulmonary Exercise Tests,Ergometry Test, Arm,Ergometry Test, Bicycle,Ergometry Tests, Arm,Ergometry Tests, Bicycle,EuroFit Test,Eurofit Test Batteries,Exercise Test, Cardiopulmonary,Exercise Testing, Cardiopulmonary,Exercise Tests,Exercise Tests, Cardiopulmonary,Fitness Testing, Physical,Fitness Testings,Step Tests,Stress Tests,Test Battery, Eurofit,Test, Arm Ergometry,Test, Bicycle Ergometry,Test, Cardiopulmonary Exercise,Test, EuroFit,Test, Exercise,Test, Step,Test, Stress,Test, Treadmill,Testing, Cardiopulmonary Exercise,Testing, Exercise,Testing, Fitness,Testing, Physical Fitness,Tests, Arm Ergometry,Tests, Bicycle Ergometry,Tests, Cardiopulmonary Exercise,Tests, EuroFit,Tests, Exercise,Tests, Step,Tests, Stress,Tests, Treadmill,Treadmill Tests
D005082 Physical Exertion Expenditure of energy during PHYSICAL ACTIVITY. Intensity of exertion may be measured by rate of OXYGEN CONSUMPTION; HEAT produced, or HEART RATE. Perceived exertion, a psychological measure of exertion, is included. Physical Effort,Effort, Physical,Efforts, Physical,Exertion, Physical,Exertions, Physical,Physical Efforts,Physical Exertions
D005260 Female Females
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000328 Adult A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available. Adults

Related Publications

K Kugiyama, and H Yasue, and K Okumura, and K Goto, and K Minoda, and H Miyagi, and K Matsuyama, and A Kojima, and Y Koga, and M Takahashi
Suppression of exercise-induced angina by magnesium sulfate in patients with variant angina.
March 1989, Journal of the American College of Cardiology,
K Kugiyama, and H Yasue, and K Okumura, and K Goto, and K Minoda, and H Miyagi, and K Matsuyama, and A Kojima, and Y Koga, and M Takahashi
Exercise-induced angina provoked by aspirin administration in patients with variant angina.
June 1981, The American journal of cardiology,
K Kugiyama, and H Yasue, and K Okumura, and K Goto, and K Minoda, and H Miyagi, and K Matsuyama, and A Kojima, and Y Koga, and M Takahashi
Magnesium sulfate in the treatment of variant angina.
January 1984, Magnesium,
K Kugiyama, and H Yasue, and K Okumura, and K Goto, and K Minoda, and H Miyagi, and K Matsuyama, and A Kojima, and Y Koga, and M Takahashi
Effect of magnesium on anginal attack induced by hyperventilation in patients with variant angina.
March 1989, Circulation,
K Kugiyama, and H Yasue, and K Okumura, and K Goto, and K Minoda, and H Miyagi, and K Matsuyama, and A Kojima, and Y Koga, and M Takahashi
Importance of magnesium deficiency in alcohol-induced variant angina.
April 1994, The American journal of cardiology,
K Kugiyama, and H Yasue, and K Okumura, and K Goto, and K Minoda, and H Miyagi, and K Matsuyama, and A Kojima, and Y Koga, and M Takahashi
[Exercise-induced attacks of variant angina pectoris].
June 1983, Kardiologiia,
K Kugiyama, and H Yasue, and K Okumura, and K Goto, and K Minoda, and H Miyagi, and K Matsuyama, and A Kojima, and Y Koga, and M Takahashi
Suppression of hyperventilation-induced attacks with infusion of atrial natriuretic peptide in patients with variant angina pectoris.
July 1993, The American journal of cardiology,
K Kugiyama, and H Yasue, and K Okumura, and K Goto, and K Minoda, and H Miyagi, and K Matsuyama, and A Kojima, and Y Koga, and M Takahashi
Coronary artery spasm during exercise in patients with variant angina.
March 1979, Circulation,
K Kugiyama, and H Yasue, and K Okumura, and K Goto, and K Minoda, and H Miyagi, and K Matsuyama, and A Kojima, and Y Koga, and M Takahashi
Circadian variation of exercise capacity in patients with Prinzmetal's variant angina: role of exercise-induced coronary arterial spasm.
May 1979, Circulation,
K Kugiyama, and H Yasue, and K Okumura, and K Goto, and K Minoda, and H Miyagi, and K Matsuyama, and A Kojima, and Y Koga, and M Takahashi
Exercise-induced S-T segment elevation in variant angina.
April 1980, The American journal of cardiology,
Copied contents to your clipboard!