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Azelastine is a chemically novel medication that has been demonstrated to be clinically effective for asthma and seasonal allergic rhinitis. In a 10-week, multicenter, double-blind, placebo-controlled, crossover study, the efficacy and safety of azelastine, 1 mg and 2 mg twice daily, were evaluated in 192 patients with symptoms of perennial allergic rhinitis. Patients maintained daily symptom and adverse-experience diaries and were evaluated every 2 weeks by the investigators. Pseudoephedrine, 30 mg, was provided as backup medication. Amelioration of most individual symptoms and a decrease in the total symptom scores were observed with both dosages of azelastine; greater improvement with 2 mg twice daily than with 1 mg twice daily, was observed. Nasal congestion, as a symptom and as reflected by rhinomanometric assessment, was the least improved parameter. Backup decongestant medication decreased during treatment with azelastine and increased during the placebo regimen. There were no major adverse effects.
E O Meltzer, and
W W Storms, and
W E Pierson, and
L H Cummins, and
H A Orgel, and
J L Perhach, and
G R Hemsworth
January 1996,
Jornal de pediatria,
E O Meltzer, and
W W Storms, and
W E Pierson, and
L H Cummins, and
H A Orgel, and
J L Perhach, and
G R Hemsworth
August 1994,
Annals of allergy,
E O Meltzer, and
W W Storms, and
W E Pierson, and
L H Cummins, and
H A Orgel, and
J L Perhach, and
G R Hemsworth
December 1990,
The Journal of allergy and clinical immunology,
E O Meltzer, and
W W Storms, and
W E Pierson, and
L H Cummins, and
H A Orgel, and
J L Perhach, and
G R Hemsworth
September 2007,
Allergology international : official journal of the Japanese Society of Allergology,
E O Meltzer, and
W W Storms, and
W E Pierson, and
L H Cummins, and
H A Orgel, and
J L Perhach, and
G R Hemsworth
July 1993,
Arzneimittel-Forschung,
E O Meltzer, and
W W Storms, and
W E Pierson, and
L H Cummins, and
H A Orgel, and
J L Perhach, and
G R Hemsworth
October 2023,
European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery,
E O Meltzer, and
W W Storms, and
W E Pierson, and
L H Cummins, and
H A Orgel, and
J L Perhach, and
G R Hemsworth
February 1989,
The Journal of allergy and clinical immunology,
E O Meltzer, and
W W Storms, and
W E Pierson, and
L H Cummins, and
H A Orgel, and
J L Perhach, and
G R Hemsworth
March 1994,
Allergy,
E O Meltzer, and
W W Storms, and
W E Pierson, and
L H Cummins, and
H A Orgel, and
J L Perhach, and
G R Hemsworth
January 2003,
Current medical research and opinion,
E O Meltzer, and
W W Storms, and
W E Pierson, and
L H Cummins, and
H A Orgel, and
J L Perhach, and
G R Hemsworth
December 1985,
Annals of allergy,
