Revisiting the pineal gland: a review of calcification, masses, precocious puberty, and melatonin functions. 2020

Shrey Patel, and Benjamin Rahmani, and Jason Gandhi, and Omar Seyam, and Gunjan Joshi, and Inefta Reid, and Noel L Smith, and Wayne C Waltzer, and Sardar Ali Khan
Department of Physiology and Biophysics, Stony Brook University Renaissance School of Medicine, Stony Brook, NY, USA.

Introduction: The pineal gland, an endocrine organ of the posterior cranial fossa famously involved in sleep and wakefulness, has continually been a topic of scientific advancement and curiosity. Methods: We review present an up-to-date review including the anatomy, embryology, and physiology of the pineal gland and its ability to secrete hormones including melatonin, pathophysiology of pineal gland tumors, cysts, and calcifications, their clinical presentation including their association with parkinsonism and precocious puberty, and various treatment approaches. Results: Exploring the biochemistry of melatonin, various calcification morphologies, and pineal tumors may uncover a wider role and the exhaustive case study consolidation allows clinicians to carefully review the literature and aid their treatment approaches. Conclusion: It is imperative that clinicians and diagnosticians are able to distinguish manifestations of an overlooked gland.

UI MeSH Term Description Entries
D008550 Melatonin A biogenic amine that is found in animals and plants. In mammals, melatonin is produced by the PINEAL GLAND. Its secretion increases in darkness and decreases during exposure to light. Melatonin is implicated in the regulation of SLEEP, mood, and REPRODUCTION. Melatonin is also an effective antioxidant.
D010870 Pineal Gland A light-sensitive neuroendocrine organ attached to the roof of the THIRD VENTRICLE of the brain. The pineal gland secretes MELATONIN, other BIOGENIC AMINES and NEUROPEPTIDES. Epiphysis Cerebri,Pineal Body,Corpus Pineale,Gland, Pineal,Pineal Bodies,Pineal Glands
D010871 Pinealoma Neoplasms which originate from pineal parenchymal cells that tend to enlarge the gland and be locally invasive. The two major forms are pineocytoma and the more malignant pineoblastoma. Pineocytomas have moderate cellularity and tend to form rosette patterns. Pineoblastomas are highly cellular tumors containing small, poorly differentiated cells. These tumors occasionally seed the neuroaxis or cause obstructive HYDROCEPHALUS or Parinaud's syndrome. GERMINOMA; CARCINOMA, EMBRYONAL; GLIOMA; and other neoplasms may arise in the pineal region with germinoma being the most common pineal region tumor. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, p2064; Adams et al., Principles of Neurology, 6th ed, p670) Neoplasms, Pineal,Pineal Neoplasms,Pinealocytoma,Pineoblastoma,Pineocytoma,Mixed Pineocytoma-Pineoblastoma,Pineal Gland Tumor,Pineal Parenchymal Tumors,Pineal Tumors,Mixed Pineocytoma Pineoblastoma,Mixed Pineocytoma-Pineoblastomas,Neoplasm, Pineal,Pineal Gland Tumors,Pineal Neoplasm,Pineal Parenchymal Tumor,Pineal Tumor,Pinealocytomas,Pinealomas,Pineoblastomas,Pineocytoma-Pineoblastoma, Mixed,Pineocytoma-Pineoblastomas, Mixed,Pineocytomas,Tumor, Pineal,Tumor, Pineal Gland,Tumor, Pineal Parenchymal,Tumors, Pineal,Tumors, Pineal Gland,Tumors, Pineal Parenchymal
D011629 Puberty, Precocious Development of SEXUAL MATURATION in boys and girls at a chronological age that is 2.5 standard deviations below the mean age at onset of PUBERTY in the population. This early maturation of the hypothalamic-pituitary-gonadal axis results in sexual precocity, elevated serum levels of GONADOTROPINS and GONADAL STEROID HORMONES such as ESTRADIOL and TESTOSTERONE. Familial Precocious Puberty,Idiopathic Sexual Precocity,Precocious Puberty,Precocious Puberty, Central,Precocious Puberty, Male Limited,Precocious Puberty, Male-Limited,Pubertas Praecox,Sexual Precocity,Testotoxicosis,Central Precocious Puberties,Central Precocious Puberty,Familial Precocious Puberties,Idiopathic Sexual Precocities,Male-Limited Precocious Puberties,Male-Limited Precocious Puberty,Praecox, Pubertas,Precocious Puberties,Precocious Puberties, Central,Precocious Puberties, Familial,Precocious Puberties, Male-Limited,Precocious Puberty, Familial,Precocities, Idiopathic Sexual,Precocities, Sexual,Precocity, Idiopathic Sexual,Precocity, Sexual,Puberties, Central Precocious,Puberties, Familial Precocious,Puberties, Male-Limited Precocious,Puberties, Precocious,Puberty, Central Precocious,Puberty, Familial Precocious,Puberty, Male-Limited Precocious,Sexual Precocities,Sexual Precocities, Idiopathic,Sexual Precocity, Idiopathic
D002114 Calcinosis Pathologic deposition of calcium salts in tissues. Calcification, Pathologic,Calcinosis, Tumoral,Microcalcification,Microcalcinosis,Pathologic Calcification,Calcinoses,Calcinoses, Tumoral,Microcalcifications,Microcalcinoses,Tumoral Calcinoses,Tumoral Calcinosis
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man

Related Publications

Shrey Patel, and Benjamin Rahmani, and Jason Gandhi, and Omar Seyam, and Gunjan Joshi, and Inefta Reid, and Noel L Smith, and Wayne C Waltzer, and Sardar Ali Khan
November 1979, Nature,
Shrey Patel, and Benjamin Rahmani, and Jason Gandhi, and Omar Seyam, and Gunjan Joshi, and Inefta Reid, and Noel L Smith, and Wayne C Waltzer, and Sardar Ali Khan
June 1954, The Journal of clinical endocrinology and metabolism,
Shrey Patel, and Benjamin Rahmani, and Jason Gandhi, and Omar Seyam, and Gunjan Joshi, and Inefta Reid, and Noel L Smith, and Wayne C Waltzer, and Sardar Ali Khan
November 1953, The Journal of endocrinology,
Shrey Patel, and Benjamin Rahmani, and Jason Gandhi, and Omar Seyam, and Gunjan Joshi, and Inefta Reid, and Noel L Smith, and Wayne C Waltzer, and Sardar Ali Khan
March 1970, Lyon medical,
Shrey Patel, and Benjamin Rahmani, and Jason Gandhi, and Omar Seyam, and Gunjan Joshi, and Inefta Reid, and Noel L Smith, and Wayne C Waltzer, and Sardar Ali Khan
January 2018, Molecules (Basel, Switzerland),
Shrey Patel, and Benjamin Rahmani, and Jason Gandhi, and Omar Seyam, and Gunjan Joshi, and Inefta Reid, and Noel L Smith, and Wayne C Waltzer, and Sardar Ali Khan
January 2008, Anales de pediatria (Barcelona, Spain : 2003),
Shrey Patel, and Benjamin Rahmani, and Jason Gandhi, and Omar Seyam, and Gunjan Joshi, and Inefta Reid, and Noel L Smith, and Wayne C Waltzer, and Sardar Ali Khan
December 1998, Indian journal of medical sciences,
Shrey Patel, and Benjamin Rahmani, and Jason Gandhi, and Omar Seyam, and Gunjan Joshi, and Inefta Reid, and Noel L Smith, and Wayne C Waltzer, and Sardar Ali Khan
January 1999, Neuro endocrinology letters,
Shrey Patel, and Benjamin Rahmani, and Jason Gandhi, and Omar Seyam, and Gunjan Joshi, and Inefta Reid, and Noel L Smith, and Wayne C Waltzer, and Sardar Ali Khan
March 2018, Indian pediatrics,
Shrey Patel, and Benjamin Rahmani, and Jason Gandhi, and Omar Seyam, and Gunjan Joshi, and Inefta Reid, and Noel L Smith, and Wayne C Waltzer, and Sardar Ali Khan
October 2023, BMC endocrine disorders,
Copied contents to your clipboard!