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Synthesis and anti-CVB3 activity of 4-amino acid derivative substituted pyrimidine nucleoside analogues. 2020
Le Tao, and
Yujiang Li, and
Xiaohe Guo, and
Lihong Dong, and
Luping Liu, and
Qiang Wang, and
Xuejun Yu, and
Chuanjun Song, and
Junbiao Chang
High & New Technology Research Center of Henan Academy of Sciences, Zhengzhou, Henan Province 450002, PR China.
Seven novel 4-amino acid derivative substituted pyrimidine nucleoside analogues were designed, synthesized, and tested for their anti-CVB3 activity. Initial biological studies indicated that among these 4-amino acid derivative substituted pyrimidine nucleoside analogues, 4-N-(2'-amino-glutaric acid-1'-methylester)-1-(2'- deoxy-2'-β-fluoro-4'-azido)-furanosyl-cytosine 2 exhibited the most potent anti-CVB activity (IC50 = 9.3 μM). The cytotoxicity of these compounds has also been assessed. The toxicity of compound 2 was similar to that of ribavirin.
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