-transparent.png){kind=logo}
Glutathione (GSH) content in livers from control and carbon tetrachloride poisoned rats treated with the calmodulin inhibitors thioridazine, imipramine or chlorpromazine. 1988
Centro de Investigaciones Toxicológicas, CITEFA/CONICET, Bs. As., Argentina.
Administration to rats of the calmodulin (CaM) inhibitors Thioridazine (TDZ) or Imipramine (IMP) (50 mg/kg ip) or Chlorpromazine (CPZ) at a dose of 25 mg/kg, ip 6 hr after olive oil or CCl4 (1 ml/kg, ip as a 20% olive oil solution) significantly increased the GSH content in liver of CCl4 poisoned animals but not in controls. The analysis of present observations and past results with Trifluoperazine, suggest that increases in GSH content in CCl4 poisoned animals treated with protective anticalmodulins are a consequence of prevention and not the cause of their preventive effects.
Related Publications
M C Villarruel, and
E C de Ferreyra, and
A S Bernacchi, and
J A Castro
September 1986,
Research communications in chemical pathology and pharmacology,
M C Villarruel, and
E C de Ferreyra, and
A S Bernacchi, and
J A Castro
January 1952,
Deutsche Zeitschrift fur Verdauungs- und Stoffwechselkrankheiten,
M C Villarruel, and
E C de Ferreyra, and
A S Bernacchi, and
J A Castro
January 1962,
Acta physiologica Academiae Scientiarum Hungaricae,
M C Villarruel, and
E C de Ferreyra, and
A S Bernacchi, and
J A Castro
January 1965,
Folia medica Cracoviensia,
M C Villarruel, and
E C de Ferreyra, and
A S Bernacchi, and
J A Castro
April 1978,
Bollettino della Societa italiana di biologia sperimentale,
M C Villarruel, and
E C de Ferreyra, and
A S Bernacchi, and
J A Castro
October 1977,
Life sciences,
M C Villarruel, and
E C de Ferreyra, and
A S Bernacchi, and
J A Castro
July 1972,
The Biochemical journal,
M C Villarruel, and
E C de Ferreyra, and
A S Bernacchi, and
J A Castro
October 1963,
Revista brasileira de biologia,
M C Villarruel, and
E C de Ferreyra, and
A S Bernacchi, and
J A Castro
August 1964,
Sbornik lekarsky,
M C Villarruel, and
E C de Ferreyra, and
A S Bernacchi, and
J A Castro
June 1987,
Journal of applied toxicology : JAT,
