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We have designed and built an inexpensive servo-respirator for use in investigations of respiratory control in small animals. The device uses a butterfly valve to alter the resistance of an outflow shunt from a manifold that connects the animal's tracheal cannula to a pressure source. Tracheal pressure is regulated in response to a command provided by a suitably processed neural signal, often the integrated phrenic neurogram. As the valve opens, tracheal pressure approaches atmospheric; as it closes, tracheal pressure approaches the source pressure. An electronic controller circuit was developed to permit experimental procedures that include withholding volume delivery while maintaining a desired level of positive end-expiratory pressure. The device is able to track the neural command signal satisfactorily, and its performance appears to be limited primarily by the constraints applied by the respiratory system mechanics.
J A Daubenspeck, and
D Pichon, and
K V Knuth, and
D Bartlett, and
W M St John
January 1965,
Activitas nervosa superior,
J A Daubenspeck, and
D Pichon, and
K V Knuth, and
D Bartlett, and
W M St John
November 1974,
Vision research,
J A Daubenspeck, and
D Pichon, and
K V Knuth, and
D Bartlett, and
W M St John
April 1984,
Agressologie: revue internationale de physio-biologie et de pharmacologie appliquees aux effets de l'agression,
J A Daubenspeck, and
D Pichon, and
K V Knuth, and
D Bartlett, and
W M St John
September 1957,
The American journal of psychology,
J A Daubenspeck, and
D Pichon, and
K V Knuth, and
D Bartlett, and
W M St John
August 1976,
Journal of applied physiology,
J A Daubenspeck, and
D Pichon, and
K V Knuth, and
D Bartlett, and
W M St John
January 1977,
Agressologie: revue internationale de physio-biologie et de pharmacologie appliquees aux effets de l'agression,
J A Daubenspeck, and
D Pichon, and
K V Knuth, and
D Bartlett, and
W M St John
April 1934,
Science (New York, N.Y.),
J A Daubenspeck, and
D Pichon, and
K V Knuth, and
D Bartlett, and
W M St John
October 2005,
IEEE transactions on systems, man, and cybernetics. Part B, Cybernetics : a publication of the IEEE Systems, Man, and Cybernetics Society,
J A Daubenspeck, and
D Pichon, and
K V Knuth, and
D Bartlett, and
W M St John
November 1981,
Microvascular research,
J A Daubenspeck, and
D Pichon, and
K V Knuth, and
D Bartlett, and
W M St John
August 1993,
Surgery, gynecology & obstetrics,
