By employing the rosette technique the peripheral T and B lymphocytes were determined in 24 patients with terminal renal failure treated by diet and 17 subjects treated by program of repeated hemodialysis. The decreased percentage of B-cells was found in both groups of patients in comparison with the control group. The more distinct decrease of B-cells was observed in patients treated by hemodialysis in comparison with undialized patients but the difference was statistically nonsignificant. The degree of immunity disturbance in chronic renal failure does not depend on dialysis but on the duration of the renal insufficiency.