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The direct determination by gas chromatography of blood levels of anesthetic agents has been difficult because of the water content of blood. In the present study, the method of Yokota et al. (1967) was modified by improving the packing materials of the column, the blood sample vaporizer and the flow-path during analysis. As a result, accurate and reproducible determination of halothane, enflurane and isoflurane dissolved in blood was achieved. With this system, blood in which halothane, enflurane and isoflurane had been dissolved could be analyzed without changing the column between samples. Moreover, each sample was prepared in less than 10 min, and more than 100 consecutive determinations could be made with excellent reproducibility. The coefficient of variation was less than 3.8%.
T Yamada, and
Y Hirai, and
S Sakano, and
M Kosaka, and
K Tada, and
S Furutani, and
F Kosaka
October 1982,
Masui. The Japanese journal of anesthesiology,
T Yamada, and
Y Hirai, and
S Sakano, and
M Kosaka, and
K Tada, and
S Furutani, and
F Kosaka
October 1988,
Masui. The Japanese journal of anesthesiology,
T Yamada, and
Y Hirai, and
S Sakano, and
M Kosaka, and
K Tada, and
S Furutani, and
F Kosaka
May 1970,
Masui. The Japanese journal of anesthesiology,
T Yamada, and
Y Hirai, and
S Sakano, and
M Kosaka, and
K Tada, and
S Furutani, and
F Kosaka
January 1982,
Masui. The Japanese journal of anesthesiology,
T Yamada, and
Y Hirai, and
S Sakano, and
M Kosaka, and
K Tada, and
S Furutani, and
F Kosaka
October 1972,
California medicine,
T Yamada, and
Y Hirai, and
S Sakano, and
M Kosaka, and
K Tada, and
S Furutani, and
F Kosaka
December 1976,
Analytical chemistry,
T Yamada, and
Y Hirai, and
S Sakano, and
M Kosaka, and
K Tada, and
S Furutani, and
F Kosaka
September 1969,
Masui. The Japanese journal of anesthesiology,
T Yamada, and
Y Hirai, and
S Sakano, and
M Kosaka, and
K Tada, and
S Furutani, and
F Kosaka
October 1971,
Masui. The Japanese journal of anesthesiology,
T Yamada, and
Y Hirai, and
S Sakano, and
M Kosaka, and
K Tada, and
S Furutani, and
F Kosaka
November 1982,
Masui. The Japanese journal of anesthesiology,
T Yamada, and
Y Hirai, and
S Sakano, and
M Kosaka, and
K Tada, and
S Furutani, and
F Kosaka
February 1969,
Masui. The Japanese journal of anesthesiology,
