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Insulin-like growth factor II is a growth factor important in fetal development. Several cancer tissues and cell lines have been reported to express IGF-II and rat IGF-II is mitogenic for breast cancer cell lines. Using Northern analysis and ribonuclease protection assays, IGF-II mRNA was detected in normal fibroblasts and in the established breast cancer cell line, T47D. In this cell line, steady state levels of IGF-II message were increased by treatment with estradiol. 10 nM IGF-II, purified from human serum, was mitogenic for breast cancer cell lines. In vitro, IGF-II may act as an autocrine growth factor for some cell lines. RNA derived from breast cancer, pathologically normal breast tissue, and benign breast disease also contained IGF-II mRNA. When paired samples of normal and cancer tissue were obtained from the breast of the same patient, the level of IGF-II mRNA expression in the normal tissue was at least that found in the cancer. This is consistent with previous observations that show IGF-II is expressed in mesenchyme. These findings suggest that in breast cancer IGF-II is produced by stromal tissue elements and potentially by the malignant epithelial cells. Therefore, IGF-II may function as an autocrine or a paracrine growth factor in different breast tumors.
D Yee, and
K J Cullen, and
S Paik, and
J F Perdue, and
B Hampton, and
A Schwartz, and
M E Lippman, and
N Rosen
September 1998,
International journal of oncology,
D Yee, and
K J Cullen, and
S Paik, and
J F Perdue, and
B Hampton, and
A Schwartz, and
M E Lippman, and
N Rosen
September 1990,
Journal of hepatology,
D Yee, and
K J Cullen, and
S Paik, and
J F Perdue, and
B Hampton, and
A Schwartz, and
M E Lippman, and
N Rosen
February 1998,
Journal of gastroenterology and hepatology,
D Yee, and
K J Cullen, and
S Paik, and
J F Perdue, and
B Hampton, and
A Schwartz, and
M E Lippman, and
N Rosen
August 1996,
Biochemical Society transactions,
D Yee, and
K J Cullen, and
S Paik, and
J F Perdue, and
B Hampton, and
A Schwartz, and
M E Lippman, and
N Rosen
March 1994,
Molecular and cellular endocrinology,
D Yee, and
K J Cullen, and
S Paik, and
J F Perdue, and
B Hampton, and
A Schwartz, and
M E Lippman, and
N Rosen
September 1991,
Journal of hepatology,
D Yee, and
K J Cullen, and
S Paik, and
J F Perdue, and
B Hampton, and
A Schwartz, and
M E Lippman, and
N Rosen
January 1991,
Progress in clinical and biological research,
D Yee, and
K J Cullen, and
S Paik, and
J F Perdue, and
B Hampton, and
A Schwartz, and
M E Lippman, and
N Rosen
November 1997,
Pancreas,
D Yee, and
K J Cullen, and
S Paik, and
J F Perdue, and
B Hampton, and
A Schwartz, and
M E Lippman, and
N Rosen
March 1998,
Virchows Archiv : an international journal of pathology,
D Yee, and
K J Cullen, and
S Paik, and
J F Perdue, and
B Hampton, and
A Schwartz, and
M E Lippman, and
N Rosen
January 1988,
Cancer treatment and research,
