BIOMAT Database Logo BIOMAT Database Logo

[Potency testing of inactivated rabies vaccines. Problems posed by the use of the Habel test]. 1979

M F Aubert, and L Andral

Rabies vaccines containing inactivated virus are often tested for potency by the Habel test. Even though many people use the Habel test, a humpbacked curve of mortality is always observed for the vaccinated mice, with a linear regression for the control animals. This unexpected survival of vaccinated mice given the greatest doses of virus is an artefact since the phenomenon is not observed after a non intracerebral challenge. Since the intracerebral challenge is not a good model for natural infection, the index of protection for the tested vaccines must be evaluated after discarding aberrant values by a graphic method. The use of the Reed and Muench method or Kärber method leads to an overestimated index of protection. The N.I.H. test gives the best estimation of the effectiveness of rabies vaccines, but does not reproduce the natural conditions of vaccination and infection.

UI MeSH Term Description Entries
D011818 Rabies Acute VIRAL CNS INFECTION affecting mammals, including humans. It is caused by RABIES VIRUS and usually spread by contamination with virus-laden saliva of bites inflicted by rabid animals. Important animal vectors include the dog, cat, bat, fox, raccoon, skunk, and wolf. Encephalitic Rabies,Furious Rabies,Hydrophobia,Paralytic Rabies,Lyssa,Furious Raby,Lyssas,Rabies, Encephalitic,Rabies, Furious,Raby, Furious
D011819 Rabies Vaccines Vaccines or candidate vaccines used to prevent and treat RABIES. The inactivated virus vaccine is used for preexposure immunization to persons at high risk of exposure, and in conjunction with rabies immunoglobulin, for postexposure prophylaxis. Rabies Human Diploid Cell Vaccine,Rabies Vaccine,Vaccine, Rabies,Vaccines, Rabies
D005069 Evaluation Studies as Topic Works about studies that determine the effectiveness or value of processes, personnel, and equipment, or the material on conducting such studies. Critique,Evaluation Indexes,Evaluation Methodology,Evaluation Report,Evaluation Research,Methodology, Evaluation,Pre-Post Tests,Qualitative Evaluation,Quantitative Evaluation,Theoretical Effectiveness,Use-Effectiveness,Critiques,Effectiveness, Theoretical,Evaluation Methodologies,Evaluation Reports,Evaluation, Qualitative,Evaluation, Quantitative,Evaluations, Qualitative,Evaluations, Quantitative,Indexes, Evaluation,Methodologies, Evaluation,Pre Post Tests,Pre-Post Test,Qualitative Evaluations,Quantitative Evaluations,Report, Evaluation,Reports, Evaluation,Research, Evaluation,Test, Pre-Post,Tests, Pre-Post,Use Effectiveness
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D001699 Biometry The use of statistical and mathematical methods to analyze biological observations and phenomena. Biometric Analysis,Biometrics,Analyses, Biometric,Analysis, Biometric,Biometric Analyses
D015164 Vaccines, Inactivated Vaccines in which the infectious microbial nucleic acid components have been destroyed by chemical or physical treatment (e.g., formalin, beta-propiolactone, gamma radiation) without affecting the antigenicity or immunogenicity of the viral coat or bacterial outer membrane proteins. Inactivated Vaccine,Killed Vaccine,Killed Vaccines,Vaccines, Killed,Inactivated Vaccines,Vaccine, Inactivated,Vaccine, Killed
D051379 Mice The common name for the genus Mus. Mice, House,Mus,Mus musculus,Mice, Laboratory,Mouse,Mouse, House,Mouse, Laboratory,Mouse, Swiss,Mus domesticus,Mus musculus domesticus,Swiss Mice,House Mice,House Mouse,Laboratory Mice,Laboratory Mouse,Mice, Swiss,Swiss Mouse,domesticus, Mus musculus

Related Publications

M F Aubert, and L Andral
[Potency testing of inactivated rabies vaccines with the antibody binding test in comparison with the NIH and habel test(author's transl)].
January 1975, Zentralblatt fur Bakteriologie, Parasitenkunde, Infektionskrankheiten und Hygiene. Erste Abteilung Originale. Reihe A: Medizinische Mikrobiologie und Parasitologie,
M F Aubert, and L Andral
Laboratory techniques in rabies: Habel test for potency.
January 1973, Monograph series. World Health Organization,
M F Aubert, and L Andral
Laboratory techniques in rabies. Habel test for potency.
January 1966, Monograph series. World Health Organization,
M F Aubert, and L Andral
Potency testing of inactivated rabies vaccines using a serological method.
January 2012, Developments in biologicals,
M F Aubert, and L Andral
Laboratory techniques in rabies. Modified Habel test for potency.
January 1966, Monograph series. World Health Organization,
M F Aubert, and L Andral
Laboratory techniques in rabies: modified Habel test for potency.
January 1973, Monograph series. World Health Organization,
M F Aubert, and L Andral
[Testing of Hempt rabies vaccine in the Habel test].
December 1958, Zentralblatt fur Bakteriologie, Parasitenkunde, Infektionskrankheiten und Hygiene. 1. Abt. Medizinisch-hygienische Bakteriologie, Virusforschung und Parasitologie. Originale,
M F Aubert, and L Andral
Potency testing of inactivated rabies vaccines in mice, dogs and cats.
January 1982, Comparative immunology, microbiology and infectious diseases,
M F Aubert, and L Andral
The rapid fluorescent focus inhibition test is a suitable method for batch potency testing of inactivated rabies vaccines.
April 2009, Biologicals : journal of the International Association of Biological Standardization,
M F Aubert, and L Andral
NIH test, a problematic method for testing potency of inactivated rabies vaccine.
August 1988, Vaccine,
Copied contents to your clipboard!