BIOMAT Database Logo BIOMAT Database Logo

Polydatin Inhibits Adipose Tissue Inflammation and Ameliorates Lipid Metabolism in High-Fat-Fed Mice. 2019

Li Zheng, and Jiayuan Wu, and Juanfen Mo, and Li Guo, and Xiaoyan Wu, and Yi Bao
The Key Laboratory, The Second Affiliated Hospital of Jiaxing University, Jiaxing, Zhejiang 314000, China.

Polydatin (PD), an active component of Chinese herbs, is reported to have many biological functions, such as cardioprotective actions, anti-inflammatory activities, and antitumor effects. In this study, we investigated the effects of PD on body weight control, glucose and lipid metabolic regulation, and anti-inflammation in a high-fat-diet- (HFD-) induced obese mice model. After treatment of PD (100 mg/kg/d for 4 weeks), HFD mice reduced body weight, retroperitoneal fat mass, and adipose cell sizes; significantly lowered serum total cholesterol triglyceride (TG) and low-density lipoprotein (LDL) levels; and increased high-density lipoprotein (HDL) levels compared with the HFD control mice. Further studies showed that PD downregulated the mRNA and protein expressions of peroxisome proliferator-activated receptor gamma (PPARγ), a transcription factor involving in the regulation of adipocyte differentiation, in the retroperitoneal fat of HFD mice. Additionally, PD significantly upregulated the mRNA and protein expressions of leptin, an adipocyte-derived anorexic hormone that regulates food intake and energy expenditure, in the adipose tissues of HFD mice. Moreover, PD reduced the expression levels of monocyte chemoattractant protein-1 (MCP-1) and tumor necrosis factor-alpha (TNF-α) in the retroperitoneal and epididymal tissues of HFD mice, suggesting that PD prevented adipose tissue inflammation. In conclusion, PD may serve as a pharmaceutic candidate for obesity-related lipid metabolism, anti-inflammation, and body weight loss.

UI MeSH Term Description Entries
D007249 Inflammation A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function. Innate Inflammatory Response,Inflammations,Inflammatory Response, Innate,Innate Inflammatory Responses
D008297 Male Males
D008810 Mice, Inbred C57BL One of the first INBRED MOUSE STRAINS to be sequenced. This strain is commonly used as genetic background for transgenic mouse models. Refractory to many tumors, this strain is also preferred model for studying role of genetic variations in development of diseases. Mice, C57BL,Mouse, C57BL,Mouse, Inbred C57BL,C57BL Mice,C57BL Mice, Inbred,C57BL Mouse,C57BL Mouse, Inbred,Inbred C57BL Mice,Inbred C57BL Mouse
D008820 Mice, Obese Mutant mice exhibiting a marked obesity coupled with overeating, hyperglycemia, hyperinsulinemia, marked insulin resistance, and infertility when in a homozygous state. They may be inbred or hybrid. Hyperglycemic Mice,Obese Mice,Mouse, Hyperglycemic,Mouse, Obese,Hyperglycemic Mouse,Mice, Hyperglycemic,Obese Mouse
D004734 Energy Metabolism The chemical reactions involved in the production and utilization of various forms of energy in cells. Bioenergetics,Energy Expenditure,Bioenergetic,Energy Expenditures,Energy Metabolisms,Expenditure, Energy,Expenditures, Energy,Metabolism, Energy,Metabolisms, Energy
D005960 Glucosides A GLYCOSIDE that is derived from GLUCOSE. Glucoside
D000273 Adipose Tissue Specialized connective tissue composed of fat cells (ADIPOCYTES). It is the site of stored FATS, usually in the form of TRIGLYCERIDES. In mammals, there are two types of adipose tissue, the WHITE FAT and the BROWN FAT. Their relative distributions vary in different species with most adipose tissue being white. Fatty Tissue,Body Fat,Fat Pad,Fat Pads,Pad, Fat,Pads, Fat,Tissue, Adipose,Tissue, Fatty
D000284 Administration, Oral The giving of drugs, chemicals, or other substances by mouth. Drug Administration, Oral,Administration, Oral Drug,Oral Administration,Oral Drug Administration,Administrations, Oral,Administrations, Oral Drug,Drug Administrations, Oral,Oral Administrations,Oral Drug Administrations
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D013267 Stilbenes Organic compounds that contain 1,2-diphenylethylene as a functional group. Stilbene,Stilbene Derivative,Stilbene Derivatives,Stilbenoid,Stilbenoids,Derivative, Stilbene,Derivatives, Stilbene

Related Publications

Li Zheng, and Jiayuan Wu, and Juanfen Mo, and Li Guo, and Xiaoyan Wu, and Yi Bao
Corosolic acid inhibits adipose tissue inflammation and ameliorates insulin resistance via AMPK activation in high-fat fed mice.
February 2016, Phytomedicine : international journal of phytotherapy and phytopharmacology,
Li Zheng, and Jiayuan Wu, and Juanfen Mo, and Li Guo, and Xiaoyan Wu, and Yi Bao
Emodin inhibits lipid accumulation and inflammation in adipose tissue of high-fat diet-fed mice by inducing M2 polarization of adipose tissue macrophages.
July 2021, FASEB journal : official publication of the Federation of American Societies for Experimental Biology,
Li Zheng, and Jiayuan Wu, and Juanfen Mo, and Li Guo, and Xiaoyan Wu, and Yi Bao
Sarsasapogenin improves adipose tissue inflammation and ameliorates insulin resistance in high-fat diet-fed C57BL/6J mice.
February 2021, Acta pharmacologica Sinica,
Li Zheng, and Jiayuan Wu, and Juanfen Mo, and Li Guo, and Xiaoyan Wu, and Yi Bao
Pectin oligosaccharides improved lipid metabolism in white adipose tissue of high-fat diet fed mice.
August 2022, Food science and biotechnology,
Li Zheng, and Jiayuan Wu, and Juanfen Mo, and Li Guo, and Xiaoyan Wu, and Yi Bao
Lactobacillus gasseri SBT2055 inhibits adipose tissue inflammation and intestinal permeability in mice fed a high-fat diet.
January 2016, Journal of nutritional science,
Li Zheng, and Jiayuan Wu, and Juanfen Mo, and Li Guo, and Xiaoyan Wu, and Yi Bao
Lipid metabolism in adipose tissue of cows fed high fat diets during lactation.
December 1995, Journal of dairy science,
Li Zheng, and Jiayuan Wu, and Juanfen Mo, and Li Guo, and Xiaoyan Wu, and Yi Bao
Niacin increases adiponectin and decreases adipose tissue inflammation in high fat diet-fed mice.
January 2013, PloS one,
Li Zheng, and Jiayuan Wu, and Juanfen Mo, and Li Guo, and Xiaoyan Wu, and Yi Bao
Dietary cocoa reduces metabolic endotoxemia and adipose tissue inflammation in high-fat fed mice.
April 2014, The Journal of nutritional biochemistry,
Li Zheng, and Jiayuan Wu, and Juanfen Mo, and Li Guo, and Xiaoyan Wu, and Yi Bao
CSAD Ameliorates Lipid Accumulation in High-Fat Diet-Fed Mice.
December 2022, International journal of molecular sciences,
Li Zheng, and Jiayuan Wu, and Juanfen Mo, and Li Guo, and Xiaoyan Wu, and Yi Bao
Role of brown adipose tissue in modulating adipose tissue inflammation and insulin resistance in high-fat diet fed mice.
July 2019, European journal of pharmacology,
Copied contents to your clipboard!