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A Mild Synthesis of 2-Substituted Benzothiazoles via Nickel-Catalyzed Intramolecular Oxidative C-H Functionalization. 2020

Ming-Yuan Gao, and Jing-Hang Li, and Shi-Bo Zhang, and Li-Jun Chen, and Yue-Sheng Li, and Zhi-Bing Dong
School of Chemistry and Environmental Engineering , Wuhan Institute of Technology , Wuhan 430205 , China.

A highly efficient synthetic method for the preparation of 2-aminobenzothiazoles starting from arylthioureas has been reported. By using a nickel catalyst, arylthioureas undergo intramolecular oxidative C-H bond functionalization, giving the desired 2-aminobenzothiazoles in good to excellent yields. This protocol features an inexpensive catalyst, low catalyst loading, mild reaction conditions, a short reaction time, and good to excellent yields, and it can be scaled up easily to a gram scale with almost no yields decreasing.

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