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Epidermal growth factor (EGF) seems to play an important role in regulating the proliferation of human breast cancer. Fifty-five primary breast tumors and 7 lymph node metastases were simultaneously assayed for the presence of EGF receptors (EGFR), estrogen receptors (ER), and progesterone receptors (PR). Overall, 42% (23/55) of the tumors were EGFR positive. EGFR were more frequently present in ER- and PR-negative than in ER- and PR-positive tumors. In particular, a negative correlation between EGFR and PR (chi 2 = 6.8; p greater than 0.01) was observed. All metastatic tumors were EGFR negative, and in all cases but 1 the levels of EGFR were higher in metastatic than in primary tumors. Our results suggest the presence of a subclass of breast tumors, the growth of which is primarily regulated by EGF or EGF-like substances rather than by steroid hormones. In this group, not amenable to endocrine therapy, EGF receptors should represent a target for therapeutic intervention.
F Battaglia, and
G Polizzi, and
G Scambia, and
S Rossi, and
P B Panici, and
S Iacobelli, and
F Crucitti, and
S Mancuso
January 1989,
Anticancer research,
F Battaglia, and
G Polizzi, and
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P B Panici, and
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F Crucitti, and
S Mancuso
March 1988,
Cancer research,
F Battaglia, and
G Polizzi, and
G Scambia, and
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P B Panici, and
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January 1988,
Cancer treatment and research,
F Battaglia, and
G Polizzi, and
G Scambia, and
S Rossi, and
P B Panici, and
S Iacobelli, and
F Crucitti, and
S Mancuso
January 1984,
Breast cancer research and treatment,
F Battaglia, and
G Polizzi, and
G Scambia, and
S Rossi, and
P B Panici, and
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F Crucitti, and
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March 1991,
Cancer,
F Battaglia, and
G Polizzi, and
G Scambia, and
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P B Panici, and
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November 1991,
Journal of surgical oncology,
F Battaglia, and
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February 1985,
Lancet (London, England),
F Battaglia, and
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January 1993,
Breast cancer research and treatment,
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March 1990,
Revista espanola de fisiologia,
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January 1996,
Acta oncologica (Stockholm, Sweden),
