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Calcium antagonism in isolated rat uterus by methylmethacrylate. 1988

C K Born, and M E Hamrick, and C P Davidson, and W R Ravis
Department of Pharmacal Sciences, School of Pharmacy, Auburn University, AL 36849.

Methylmethacrylate (MMA) was evaluated for the ability to block actions of calcium in the isolated rat uterine preparation. MMA blocked receptor-mediated contraction and the phasic and tonic portions of the KCl induced contraction of the uterus. The effects of MMA could be antagonized by increasing the concentration of calcium. In the Ca++-free, K-depolarized preparation, MMA produced dose related depression of contraction.

UI MeSH Term Description Entries
D008768 Methylmethacrylates The methyl esters of methacrylic acid that polymerize easily and are used as tissue cements, dental materials, and absorbent for biological substances.
D011919 Rats, Inbred Strains Genetically identical individuals developed from brother and sister matings which have been carried out for twenty or more generations or by parent x offspring matings carried out with certain restrictions. This also includes animals with a long history of closed colony breeding. August Rats,Inbred Rat Strains,Inbred Strain of Rat,Inbred Strain of Rats,Inbred Strains of Rats,Rat, Inbred Strain,August Rat,Inbred Rat Strain,Inbred Strain Rat,Inbred Strain Rats,Inbred Strains Rat,Inbred Strains Rats,Rat Inbred Strain,Rat Inbred Strains,Rat Strain, Inbred,Rat Strains, Inbred,Rat, August,Rat, Inbred Strains,Rats Inbred Strain,Rats Inbred Strains,Rats, August,Rats, Inbred Strain,Strain Rat, Inbred,Strain Rats, Inbred,Strain, Inbred Rat,Strains, Inbred Rat
D002121 Calcium Channel Blockers A class of drugs that act by selective inhibition of calcium influx through cellular membranes. Calcium Antagonists, Exogenous,Calcium Blockaders, Exogenous,Calcium Channel Antagonist,Calcium Channel Blocker,Calcium Channel Blocking Drug,Calcium Inhibitors, Exogenous,Channel Blockers, Calcium,Exogenous Calcium Blockader,Exogenous Calcium Inhibitor,Calcium Channel Antagonists,Calcium Channel Blocking Drugs,Exogenous Calcium Antagonists,Exogenous Calcium Blockaders,Exogenous Calcium Inhibitors,Antagonist, Calcium Channel,Antagonists, Calcium Channel,Antagonists, Exogenous Calcium,Blockader, Exogenous Calcium,Blocker, Calcium Channel,Blockers, Calcium Channel,Calcium Blockader, Exogenous,Calcium Inhibitor, Exogenous,Channel Antagonist, Calcium,Channel Blocker, Calcium,Inhibitor, Exogenous Calcium
D004305 Dose-Response Relationship, Drug The relationship between the dose of an administered drug and the response of the organism to the drug. Dose Response Relationship, Drug,Dose-Response Relationships, Drug,Drug Dose-Response Relationship,Drug Dose-Response Relationships,Relationship, Drug Dose-Response,Relationships, Drug Dose-Response
D005260 Female Females
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D014590 Uterine Contraction Contraction of the UTERINE MUSCLE. Myometrial Contraction,Contraction, Myometrial,Contraction, Uterine,Contractions, Myometrial,Contractions, Uterine,Myometrial Contractions,Uterine Contractions
D051381 Rats The common name for the genus Rattus. Rattus,Rats, Laboratory,Rats, Norway,Rattus norvegicus,Laboratory Rat,Laboratory Rats,Norway Rat,Norway Rats,Rat,Rat, Laboratory,Rat, Norway,norvegicus, Rattus
D020366 Methylmethacrylate The methyl ester of methacrylic acid. It polymerizes easily to form POLYMETHYL METHACRYLATE. It is used as a bone cement. Methylmethacrylate Methyl Monomer,Cranioplast,Kallocryl,Kallocryl A,Metaplex,Methacrylate Methyl Monomer,Simplex P,Sintex,Zimmer Bone Cement,Bone Cement, Zimmer,Bone Cements, Zimmer,Cement, Zimmer Bone,Cements, Zimmer Bone,Cranioplasts,Kallocryls,Metaplices,Methacrylate Methyl Monomers,Methyl Monomer, Methacrylate,Methyl Monomer, Methylmethacrylate,Methyl Monomers, Methacrylate,Methyl Monomers, Methylmethacrylate,Methylmethacrylate Methyl Monomers,Monomer, Methacrylate Methyl,Monomer, Methylmethacrylate Methyl,Monomers, Methacrylate Methyl,Monomers, Methylmethacrylate Methyl,Sintices,Zimmer Bone Cements

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