Biomaterial Database

The prophylactic use of propylic ester of p-hydrobenzoic acid on alveolitis sicca dolorosa. A preliminary report. 1977

M Ritzau, and K Swangsilpa

A double-blind experiment was performed to test the possible prophylactic effect of the antifibrinolytically active propylic ester of p-hydroxybenzoic acid (PEPH) on alveolitis sicca dolorosa (dry socket). Tablets containing PEPH or placebo were inserted at random selection into the alveoli of forty-five consecutive patients, each of whom had had an impacted mandibular third molar removed. The prophylactic effect of PEPH in this study was found to be highly significant as compared to that of placebo, and no patients in the experimental group developed alveolitis sicca dolorosa.

UI	MeSH Term	Description	Entries
D008297	Male		Males
D008875	Middle Aged	An adult aged 45 - 64 years.	Middle Age
D008963	Molar	The most posterior teeth on either side of the jaw, totaling eight in the deciduous dentition (2 on each side, upper and lower), and usually 12 in the permanent dentition (three on each side, upper and lower). They are grinding teeth, having large crowns and broad chewing surfaces. (Jablonski, Dictionary of Dentistry, 1992, p821)	Molars
D010226	Parabens	Methyl, propyl, butyl, and ethyl esters of p-hydroxybenzoic acid. They have been approved by the FDA as antimicrobial agents for foods and pharmaceuticals. (From Hawley's Condensed Chemical Dictionary, 11th ed, p872)	4-Hydroxybenzoic Acids,Paraben,para-Hydroxybenzoic Acids,4 Hydroxybenzoic Acids,para Hydroxybenzoic Acids
D010919	Placebos	Any dummy medication or treatment. Although placebos originally were medicinal preparations having no specific pharmacological activity against a targeted condition, the concept has been extended to include treatments or procedures, especially those administered to control groups in clinical trials in order to provide baseline measurements for the experimental protocol.	Sham Treatment
D002986	Clinical Trials as Topic	Works about pre-planned studies of the safety, efficacy, or optimum dosage schedule (if appropriate) of one or more diagnostic, therapeutic, or prophylactic drugs, devices, or techniques selected according to predetermined criteria of eligibility and observed for predefined evidence of favorable and unfavorable effects. This concept includes clinical trials conducted both in the U.S. and in other countries.	Clinical Trial as Topic
D004368	Dry Socket	A condition sometimes occurring after tooth extraction, particularly after traumatic extraction, resulting in a dry appearance of the exposed bone in the socket, due to disintegration or loss of the blood clot. It is basically a focal osteomyelitis without suppuration and is accompanied by severe pain (alveolalgia) and foul odor. (Dorland, 28th ed)	Alveolalgia,Alveolar Osteitis,Alveolar Periostitis,Alveolitis Sicca Dolorosa,Osteitis, Alveolar,Periostitis, Alveolar,Alveolalgias,Alveolar Osteitides,Alveolar Periostitides,Dry Sockets,Osteitides, Alveolar,Periostitides, Alveolar,Socket, Dry,Sockets, Dry
D005260	Female		Females
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000293	Adolescent	A person 13 to 18 years of age.	Adolescence,Youth,Adolescents,Adolescents, Female,Adolescents, Male,Teenagers,Teens,Adolescent, Female,Adolescent, Male,Female Adolescent,Female Adolescents,Male Adolescent,Male Adolescents,Teen,Teenager,Youths