Biomaterial Database

Distinct relationships of amyloid-beta and tau deposition to cerebral glucose metabolic networks in Alzheimer's disease. 2020

Xi Sun, and Binbin Nie, and Shujun Zhao, and Lin Ai, and Qian Chen, and Tianhao Zhang, and Tingting Pan, and Luying Wang, and Xiaolong Yin, and Wei Zhang, and Baoci Shan, and Hua Liu, and Shengxiang Liang, and Guihong Wang

College of Physical Science and Technology, Zhengzhou University, Zhengzhou 450001, China; Beijing Engineering Research Center of Radiographic Techniques and Equipment, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049, China.

Extracellular accumulation of amyloid-beta peptides and intracellular neurofibrillary tangles (NFTs) of hyperphosphorylated tau proteins are the two cardinally pathological hallmarks of Alzheimer's disease (AD). However, their exact roles in the mechanisms of AD progression are not well established. Given that AD is a disconnection syndrome and hypometabolism is one of its most important neurodegenerative indicators, we hypothesized amyloid-beta and tau burden may disturb the glucose metabolic network of AD. Here we investigated the relationship of these two factors to regional metabolic network properties using multimodal positron emission tomography (PET) imaging data. Participants included six groups covering from cognitively normal controls, patients with early cognitive impairment (MCI), late MCI, mild AD, moderate AD to severe AD who underwent amyloid-beta PET, tau PET and fluorodeoxyglucose (FDG) PET. Glucose metabolic network of each group was constructed and relations of amyloid-beta and tau to regional metabolic network measurements were investigated. Results revealed distinct associations of these two hallmarks to metabolic networks: amyloid-beta were positively related to metabolic network measurements at relative early phases of AD, while tau burden showed a negative relationship at late phase of AD. These results supported the notion that amyloid-beta and tau accumulation may contribute independently to mechanisms of AD. Furthermore, these findings might also provide connectivity evidence for the speculation that amyloid-beta deposition is protective to neuronal activity.

UI	MeSH Term	Description	Entries
D008297	Male		Males
D008875	Middle Aged	An adult aged 45 - 64 years.	Middle Age
D001921	Brain	The part of CENTRAL NERVOUS SYSTEM that is contained within the skull (CRANIUM). Arising from the NEURAL TUBE, the embryonic brain is comprised of three major parts including PROSENCEPHALON (the forebrain); MESENCEPHALON (the midbrain); and RHOMBENCEPHALON (the hindbrain). The developed brain consists of CEREBRUM; CEREBELLUM; and other structures in the BRAIN STEM.	Encephalon
D003071	Cognition	Intellectual or mental process whereby an organism obtains knowledge.	Cognitive Function,Cognitions,Cognitive Functions,Function, Cognitive,Functions, Cognitive
D005260	Female		Females
D005947	Glucose	A primary source of energy for living organisms. It is naturally occurring and is found in fruits and other parts of plants in its free state. It is used therapeutically in fluid and nutrient replacement.	Dextrose,Anhydrous Dextrose,D-Glucose,Glucose Monohydrate,Glucose, (DL)-Isomer,Glucose, (alpha-D)-Isomer,Glucose, (beta-D)-Isomer,D Glucose,Dextrose, Anhydrous,Monohydrate, Glucose
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000368	Aged	A person 65 years of age or older. For a person older than 79 years, AGED, 80 AND OVER is available.	Elderly
D000369	Aged, 80 and over	Persons 80 years of age and older.	Oldest Old
D000544	Alzheimer Disease	A degenerative disease of the BRAIN characterized by the insidious onset of DEMENTIA. Impairment of MEMORY, judgment, attention span, and problem solving skills are followed by severe APRAXIAS and a global loss of cognitive abilities. The condition primarily occurs after age 60, and is marked pathologically by severe cortical atrophy and the triad of SENILE PLAQUES; NEUROFIBRILLARY TANGLES; and NEUROPIL THREADS. (From Adams et al., Principles of Neurology, 6th ed, pp1049-57)	Acute Confusional Senile Dementia,Alzheimer's Diseases,Dementia, Alzheimer Type,Dementia, Senile,Presenile Alzheimer Dementia,Senile Dementia, Alzheimer Type,Alzheimer Dementia,Alzheimer Disease, Early Onset,Alzheimer Disease, Late Onset,Alzheimer Sclerosis,Alzheimer Syndrome,Alzheimer Type Senile Dementia,Alzheimer's Disease,Alzheimer's Disease, Focal Onset,Alzheimer-Type Dementia (ATD),Dementia, Presenile,Dementia, Primary Senile Degenerative,Early Onset Alzheimer Disease,Familial Alzheimer Disease (FAD),Focal Onset Alzheimer's Disease,Late Onset Alzheimer Disease,Primary Senile Degenerative Dementia,Senile Dementia, Acute Confusional,Alzheimer Dementias,Alzheimer Disease, Familial (FAD),Alzheimer Diseases,Alzheimer Type Dementia,Alzheimer Type Dementia (ATD),Alzheimers Diseases,Dementia, Alzheimer,Dementia, Alzheimer-Type (ATD),Familial Alzheimer Diseases (FAD),Presenile Dementia,Sclerosis, Alzheimer,Senile Dementia