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Aggregation of platelets, stimulated by different agonists, was inhibited by omitting sample stirring or by preincubation of platelets with a monoclonal antibody against glycoproteins IIb-IIIa or with a pentapeptide containing the sequence Arg-Gly-Asp-Ser. In platelets stimulated by collagen, ADP and epinephrine, the inhibition of aggregation paralleled a reduction of both release reaction and thromboxane A2 formation. When thrombin was the stimulus, ATP release and thromboxane A2 production were unaffected (or only slightly modified) by the inhibition of platelet aggregation. These data add further evidence to the hypothesis that aggregation supports the activation of platelets stimulated by weak agonists.
C L Balduini, and
G Bertolino, and
P Noris, and
F Sinigaglia, and
A Bisio, and
M Torti
August 1981,
The American journal of pathology,
C L Balduini, and
G Bertolino, and
P Noris, and
F Sinigaglia, and
A Bisio, and
M Torti
January 1988,
Archives internationales de pharmacodynamie et de therapie,
C L Balduini, and
G Bertolino, and
P Noris, and
F Sinigaglia, and
A Bisio, and
M Torti
November 2008,
Journal of thrombosis and haemostasis : JTH,
C L Balduini, and
G Bertolino, and
P Noris, and
F Sinigaglia, and
A Bisio, and
M Torti
January 1991,
Archives of toxicology. Supplement. = Archiv fur Toxikologie. Supplement,
C L Balduini, and
G Bertolino, and
P Noris, and
F Sinigaglia, and
A Bisio, and
M Torti
March 1991,
Thrombosis and haemostasis,
C L Balduini, and
G Bertolino, and
P Noris, and
F Sinigaglia, and
A Bisio, and
M Torti
June 1991,
Thrombosis research,
C L Balduini, and
G Bertolino, and
P Noris, and
F Sinigaglia, and
A Bisio, and
M Torti
February 1986,
The Biochemical journal,
C L Balduini, and
G Bertolino, and
P Noris, and
F Sinigaglia, and
A Bisio, and
M Torti
January 1982,
Haemostasis,
C L Balduini, and
G Bertolino, and
P Noris, and
F Sinigaglia, and
A Bisio, and
M Torti
January 1987,
Advances in prostaglandin, thromboxane, and leukotriene research,
C L Balduini, and
G Bertolino, and
P Noris, and
F Sinigaglia, and
A Bisio, and
M Torti
January 1980,
Advances in prostaglandin and thromboxane research,
