BIOMAT Database Logo BIOMAT Database Logo

A Unique Brain Connectome Fingerprint Predates and Predicts Response to Antidepressants. 2020

Samaneh Nemati, and Teddy J Akiki, and Jeremy Roscoe, and Yumeng Ju, and Christopher L Averill, and Samar Fouda, and Arpan Dutta, and Shane McKie, and John H Krystal, and J F William Deakin, and Lynnette A Averill, and Chadi G Abdallah
National Center for PTSD - Clinical Neuroscience Division, US Department of Veterans Affairs, 950 Campbell Avenue 151 E, West Haven, CT 06516, USA; Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.

More than six decades have passed since the discovery of monoaminergic antidepressants. Yet, it remains a mystery why these drugs take weeks to months to achieve therapeutic effects, although their monoaminergic actions are present rapidly after treatment. In an attempt to solve this mystery, rather than studying the acute neurochemical effects of antidepressants, here we propose focusing on the early changes in the brain functional connectome using traditional statistics and machine learning approaches. Capitalizing on three independent datasets (n = 1,261) and recent developments in data and network science, we identified a specific connectome fingerprint that predates and predicts response to monoaminergic antidepressants. The discovered fingerprint appears to generalize to antidepressants with differing mechanism of action. We also established a consensus whole-brain hierarchical connectivity architecture and provided a set of model-based features engineering approaches suitable for identifying connectomic signatures of brain function in health and disease.

UI MeSH Term Description Entries

Related Publications

Samaneh Nemati, and Teddy J Akiki, and Jeremy Roscoe, and Yumeng Ju, and Christopher L Averill, and Samar Fouda, and Arpan Dutta, and Shane McKie, and John H Krystal, and J F William Deakin, and Lynnette A Averill, and Chadi G Abdallah
The developing brain structural and functional connectome fingerprint.
June 2022, Developmental cognitive neuroscience,
Samaneh Nemati, and Teddy J Akiki, and Jeremy Roscoe, and Yumeng Ju, and Christopher L Averill, and Samar Fouda, and Arpan Dutta, and Shane McKie, and John H Krystal, and J F William Deakin, and Lynnette A Averill, and Chadi G Abdallah
A robust and reproducible connectome fingerprint of ketamine is highly associated with the connectomic signature of antidepressants.
January 2021, Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology,
Samaneh Nemati, and Teddy J Akiki, and Jeremy Roscoe, and Yumeng Ju, and Christopher L Averill, and Samar Fouda, and Arpan Dutta, and Shane McKie, and John H Krystal, and J F William Deakin, and Lynnette A Averill, and Chadi G Abdallah
Stability of the Brain Functional Connectome Fingerprint in Individuals With Schizophrenia.
July 2018, JAMA psychiatry,
Samaneh Nemati, and Teddy J Akiki, and Jeremy Roscoe, and Yumeng Ju, and Christopher L Averill, and Samar Fouda, and Arpan Dutta, and Shane McKie, and John H Krystal, and J F William Deakin, and Lynnette A Averill, and Chadi G Abdallah
Commentary: Functional connectome fingerprint: identifying individuals using patterns of brain connectivity.
January 2017, Frontiers in human neuroscience,
Samaneh Nemati, and Teddy J Akiki, and Jeremy Roscoe, and Yumeng Ju, and Christopher L Averill, and Samar Fouda, and Arpan Dutta, and Shane McKie, and John H Krystal, and J F William Deakin, and Lynnette A Averill, and Chadi G Abdallah
Variation in GNB3 predicts response and adverse reactions to antidepressants.
July 2011, Journal of psychopharmacology (Oxford, England),
Samaneh Nemati, and Teddy J Akiki, and Jeremy Roscoe, and Yumeng Ju, and Christopher L Averill, and Samar Fouda, and Arpan Dutta, and Shane McKie, and John H Krystal, and J F William Deakin, and Lynnette A Averill, and Chadi G Abdallah
When makes you unique: Temporality of the human brain fingerprint.
October 2021, Science advances,
Samaneh Nemati, and Teddy J Akiki, and Jeremy Roscoe, and Yumeng Ju, and Christopher L Averill, and Samar Fouda, and Arpan Dutta, and Shane McKie, and John H Krystal, and J F William Deakin, and Lynnette A Averill, and Chadi G Abdallah
Functional connectome fingerprint of holistic-analytic cultural style.
February 2022, Social cognitive and affective neuroscience,
Samaneh Nemati, and Teddy J Akiki, and Jeremy Roscoe, and Yumeng Ju, and Christopher L Averill, and Samar Fouda, and Arpan Dutta, and Shane McKie, and John H Krystal, and J F William Deakin, and Lynnette A Averill, and Chadi G Abdallah
Connectome-Based Model Predicts Deep Brain Stimulation Outcome in Parkinson's Disease.
January 2020, Frontiers in computational neuroscience,
Samaneh Nemati, and Teddy J Akiki, and Jeremy Roscoe, and Yumeng Ju, and Christopher L Averill, and Samar Fouda, and Arpan Dutta, and Shane McKie, and John H Krystal, and J F William Deakin, and Lynnette A Averill, and Chadi G Abdallah
The connectome predicts resting-state functional connectivity across the Drosophila brain.
June 2021, Current biology : CB,
Samaneh Nemati, and Teddy J Akiki, and Jeremy Roscoe, and Yumeng Ju, and Christopher L Averill, and Samar Fouda, and Arpan Dutta, and Shane McKie, and John H Krystal, and J F William Deakin, and Lynnette A Averill, and Chadi G Abdallah
Poor response to antidepressants predicts new suicidal ideas and behavior in depressed outpatients.
October 2014, European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology,
Copied contents to your clipboard!