-transparent.png){kind=logo}
Recent studies have demonstrated that transient (1 h) hepatic arterial ischaemia is followed by increased incorporation of labelled thymidine into tumour DNA 24 h later. The present study aimed at investigating if and when there is a corresponding increase in incorporation of labelled 5-fluorouracil (5-FU) or orotic acid into tumour tissue. Incorporation was studied at 0, 6, 24 and 48 h after discontinuation of transient hepatic arterial ischaemia in Wistar-Furth rats having liver tumour. The transient ischaemia was followed by increased RNA and RNA/DNA ratios in normal liver but not in tumour. Incorporation of orotic acid into RNA and DNA was unchanged in tumour but increased at 0 and 6 h in normal liver. Incorporation of 5-FU decreased with time in liver and tumour DNA and in tumour RNA. It is suggested that 5-FU has an optimal effect on tumour tissue when infused immediately after transient hepatic arterial ischaemia.
P Mack, and
K G Tranberg, and
U Strenram, and
B Jeppsson, and
D Widlus, and
S Bengmark
November 1980,
Bollettino della Societa italiana di biologia sperimentale,
P Mack, and
K G Tranberg, and
U Strenram, and
B Jeppsson, and
D Widlus, and
S Bengmark
January 1984,
Advances in experimental medicine and biology,
P Mack, and
K G Tranberg, and
U Strenram, and
B Jeppsson, and
D Widlus, and
S Bengmark
June 1986,
European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology,
P Mack, and
K G Tranberg, and
U Strenram, and
B Jeppsson, and
D Widlus, and
S Bengmark
December 1974,
Research communications in chemical pathology and pharmacology,
P Mack, and
K G Tranberg, and
U Strenram, and
B Jeppsson, and
D Widlus, and
S Bengmark
April 2010,
Chinese medical journal,
P Mack, and
K G Tranberg, and
U Strenram, and
B Jeppsson, and
D Widlus, and
S Bengmark
June 1969,
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.),
P Mack, and
K G Tranberg, and
U Strenram, and
B Jeppsson, and
D Widlus, and
S Bengmark
December 1970,
Archives of biochemistry and biophysics,
P Mack, and
K G Tranberg, and
U Strenram, and
B Jeppsson, and
D Widlus, and
S Bengmark
November 1974,
Bollettino della Societa italiana di biologia sperimentale,
P Mack, and
K G Tranberg, and
U Strenram, and
B Jeppsson, and
D Widlus, and
S Bengmark
November 1987,
The American journal of anatomy,
P Mack, and
K G Tranberg, and
U Strenram, and
B Jeppsson, and
D Widlus, and
S Bengmark
January 1987,
The International journal of biochemistry,
