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The isotype distribution of human IgG antibodies reactive with common dietary proteins has been evaluated in sera from adult patients with the irritable bowel syndrome and with bronchial asthma using a solid-phase immunoassay (ELISA). In both these medical disorders, serum antibodies reactive with ovalbumin or gliadin were restricted predominantly to the IgG4 isotype; however, IgG antibodies reactive with bovine milk antigens, notably casein, were often restricted to both the IgG2 and IgG4 isotypes. A similar serum IgG antibody isotype distribution for these dietary protein antigens was also demonstrated in IgG antibody-positive healthy adults. These data amplify the view that production of antibodies of the IgG4 isotype may reflect a normal immune response to dietary protein antigens presented at mucosal surfaces.
R M Barnes, and
P M Johnson, and
M M Harvey, and
J Blears, and
R Finn
January 1992,
Clinical immunology and immunopathology,
R M Barnes, and
P M Johnson, and
M M Harvey, and
J Blears, and
R Finn
January 1988,
Monographs in allergy,
R M Barnes, and
P M Johnson, and
M M Harvey, and
J Blears, and
R Finn
September 1989,
The Journal of allergy and clinical immunology,
R M Barnes, and
P M Johnson, and
M M Harvey, and
J Blears, and
R Finn
February 1994,
Journal of autoimmunity,
R M Barnes, and
P M Johnson, and
M M Harvey, and
J Blears, and
R Finn
October 1987,
Immunology letters,
R M Barnes, and
P M Johnson, and
M M Harvey, and
J Blears, and
R Finn
June 1986,
Clinical and experimental immunology,
R M Barnes, and
P M Johnson, and
M M Harvey, and
J Blears, and
R Finn
January 1986,
Monographs in allergy,
R M Barnes, and
P M Johnson, and
M M Harvey, and
J Blears, and
R Finn
January 1989,
Acta dermato-venereologica. Supplementum,
R M Barnes, and
P M Johnson, and
M M Harvey, and
J Blears, and
R Finn
October 1985,
Journal of immunological methods,
R M Barnes, and
P M Johnson, and
M M Harvey, and
J Blears, and
R Finn
January 1989,
Viral immunology,
