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A re-usable mobile catheterization apparatus was developed that permits multiple blood samples to be obtained from nonrestrained and unanesthetized mice. The collection end of the catheter is located outside the cage allowing the mouse to remain completely undisturbed prior to and during blood collection. The apparatus was used in adult mice surgically fitted under pentobarbital anesthesia with right atrial silastic catheters. Sample volume and collection frequency are easily controlled without subjecting the animal to repetitive trauma. Low plasma corticosterone concentrations confirmed the nonstressful quality of the technique. Full catheter patency in mice averaged 21.5 days. The tethering apparatus design was easily upscaled to accommodate use in adult rats.
J N MacLeod, and
B H Shapiro
January 1983,
Acta veterinaria Scandinavica,
J N MacLeod, and
B H Shapiro
October 2002,
Brain research. Brain research protocols,
J N MacLeod, and
B H Shapiro
July 1997,
Physiology & behavior,
J N MacLeod, and
B H Shapiro
September 1998,
Contemporary topics in laboratory animal science,
J N MacLeod, and
B H Shapiro
October 1984,
Drug intelligence & clinical pharmacy,
J N MacLeod, and
B H Shapiro
October 1987,
The American journal of physiology,
J N MacLeod, and
B H Shapiro
June 1992,
Laboratory animal science,
J N MacLeod, and
B H Shapiro
February 1997,
Neonatal network : NN,
J N MacLeod, and
B H Shapiro
March 1981,
Physiology & behavior,
J N MacLeod, and
B H Shapiro
January 1988,
JPEN. Journal of parenteral and enteral nutrition,
