Genetic Polymorphism of Mismatch Repair Genes and Susceptibility to Prostate Cancer. 2020

Paniz Khooshemehri, and Seyed Hamid Jamaldini, and Seyed Amir Mohsen Ziaee, and Mahdi Afshari, and Mahshid Sattari, and Behzad Narouie, and Mehdi Sotoudeh, and Vahideh Montazeri, and Negar Sarhangi, and Mandana Hasanzad
Medical Genomics Research Center, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran. paniz.khooshemehri@gmail.com.

Mismatch repair (MMR) is one of the DNA repair systems that correct mispaired bases during DNA replication errors. Polymorphisms in genes can increase susceptibility to the development of prostate cancer (PCa). In this study, we investigated mutL homolog 1 (MLH1) -93G>A (rs1800734) and mutS homolog 3 (MSH3) (rs26279) polymorphisms with the risk of PCa. In this study of Iranian population, 175 histopathologically confirmed (PCa) patients and 230 benign prostate hyperplasia (BPH) as the controls were recruited. The genotypes of MLH1 and MSH3 were determined by polymerase chain reaction and restriction fragment length polymorphism (PCR-RFLP) method. There was no significant difference of MLH1 (P = 0.4) and MSH3 (P?=?0.5) genotype distributions among PCa cases and controls. And also patients with PCa were not significant differences compared to those without in stage of cancer, grade of tumor, perineural invasion, and vascular invasion. Our results did not show adequate evidence for any significant association of MLH1 and MSH3 polymorphisms and PCa .

UI MeSH Term Description Entries
D007492 Iran A country bordering the Gulf of Oman, the Persian Gulf, and the Caspian Sea, between Iraq and Pakistan. The capital is Tehran. Islamic Republic of Iran
D008297 Male Males
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D011471 Prostatic Neoplasms Tumors or cancer of the PROSTATE. Cancer of Prostate,Prostate Cancer,Cancer of the Prostate,Neoplasms, Prostate,Neoplasms, Prostatic,Prostate Neoplasms,Prostatic Cancer,Cancer, Prostate,Cancer, Prostatic,Cancers, Prostate,Cancers, Prostatic,Neoplasm, Prostate,Neoplasm, Prostatic,Prostate Cancers,Prostate Neoplasm,Prostatic Cancers,Prostatic Neoplasm
D012150 Polymorphism, Restriction Fragment Length Variation occurring within a species in the presence or length of DNA fragment generated by a specific endonuclease at a specific site in the genome. Such variations are generated by mutations that create or abolish recognition sites for these enzymes or change the length of the fragment. RFLP,Restriction Fragment Length Polymorphism,RFLPs,Restriction Fragment Length Polymorphisms
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000070957 MutL Protein Homolog 1 Eukaryotic homolog of the bacterial MutL DNA MISMATCH REPAIR protein. It heterodimerizes with MISMATCH REPAIR ENDONUCLEASE PMS2 to form MutL alpha, which is recruited to DNA mismatch sites by the MUTS DNA MISMATCH-BINDING PROTEIN. Mutations in the human MLH1 gene are associated with COLORECTAL NEOPLASMS, HEREDITARY NONPOLYPOSIS. COCA2 Protein,Colon Cancer, Nonpolyposis Type 2 Protein,MLH1 Protein,MutL Homolog 1
D000074081 MutS Homolog 3 Protein A MutS homolog protein and component of post-replicative DNA MISMATCH REPAIR. It forms a heterodimer with MUTS HOMOLOG 2 PROTEIN (MSH2) and recognizes large insertion-deletion loops up to 13 nucleotides in length. This directs downstream events such as strand discrimination, excision, and resynthesis. Mismatch Repair Protein 1
D000368 Aged A person 65 years of age or older. For a person older than 79 years, AGED, 80 AND OVER is available. Elderly
D016022 Case-Control Studies Comparisons that start with the identification of persons with the disease or outcome of interest and a control (comparison, referent) group without the disease or outcome of interest. The relationship of an attribute is examined by comparing both groups with regard to the frequency or levels of outcome over time. Case-Base Studies,Case-Comparison Studies,Case-Referent Studies,Matched Case-Control Studies,Nested Case-Control Studies,Case Control Studies,Case-Compeer Studies,Case-Referrent Studies,Case Base Studies,Case Comparison Studies,Case Control Study,Case Referent Studies,Case Referrent Studies,Case-Comparison Study,Case-Control Studies, Matched,Case-Control Studies, Nested,Case-Control Study,Case-Control Study, Matched,Case-Control Study, Nested,Case-Referent Study,Case-Referrent Study,Matched Case Control Studies,Matched Case-Control Study,Nested Case Control Studies,Nested Case-Control Study,Studies, Case Control,Studies, Case-Base,Studies, Case-Comparison,Studies, Case-Compeer,Studies, Case-Control,Studies, Case-Referent,Studies, Case-Referrent,Studies, Matched Case-Control,Studies, Nested Case-Control,Study, Case Control,Study, Case-Comparison,Study, Case-Control,Study, Case-Referent,Study, Case-Referrent,Study, Matched Case-Control,Study, Nested Case-Control

Related Publications

Paniz Khooshemehri, and Seyed Hamid Jamaldini, and Seyed Amir Mohsen Ziaee, and Mahdi Afshari, and Mahshid Sattari, and Behzad Narouie, and Mehdi Sotoudeh, and Vahideh Montazeri, and Negar Sarhangi, and Mandana Hasanzad
March 2015, Experimental oncology,
Paniz Khooshemehri, and Seyed Hamid Jamaldini, and Seyed Amir Mohsen Ziaee, and Mahdi Afshari, and Mahshid Sattari, and Behzad Narouie, and Mehdi Sotoudeh, and Vahideh Montazeri, and Negar Sarhangi, and Mandana Hasanzad
November 2005, Zhonghua wai ke za zhi [Chinese journal of surgery],
Paniz Khooshemehri, and Seyed Hamid Jamaldini, and Seyed Amir Mohsen Ziaee, and Mahdi Afshari, and Mahshid Sattari, and Behzad Narouie, and Mehdi Sotoudeh, and Vahideh Montazeri, and Negar Sarhangi, and Mandana Hasanzad
October 2015, Archives of medical research,
Paniz Khooshemehri, and Seyed Hamid Jamaldini, and Seyed Amir Mohsen Ziaee, and Mahdi Afshari, and Mahshid Sattari, and Behzad Narouie, and Mehdi Sotoudeh, and Vahideh Montazeri, and Negar Sarhangi, and Mandana Hasanzad
December 1994, Current opinion in biotechnology,
Paniz Khooshemehri, and Seyed Hamid Jamaldini, and Seyed Amir Mohsen Ziaee, and Mahdi Afshari, and Mahshid Sattari, and Behzad Narouie, and Mehdi Sotoudeh, and Vahideh Montazeri, and Negar Sarhangi, and Mandana Hasanzad
June 2015, Clinical genetics,
Paniz Khooshemehri, and Seyed Hamid Jamaldini, and Seyed Amir Mohsen Ziaee, and Mahdi Afshari, and Mahshid Sattari, and Behzad Narouie, and Mehdi Sotoudeh, and Vahideh Montazeri, and Negar Sarhangi, and Mandana Hasanzad
October 1995, Trends in biochemical sciences,
Paniz Khooshemehri, and Seyed Hamid Jamaldini, and Seyed Amir Mohsen Ziaee, and Mahdi Afshari, and Mahshid Sattari, and Behzad Narouie, and Mehdi Sotoudeh, and Vahideh Montazeri, and Negar Sarhangi, and Mandana Hasanzad
January 1988, Nouvelle revue francaise d'hematologie,
Paniz Khooshemehri, and Seyed Hamid Jamaldini, and Seyed Amir Mohsen Ziaee, and Mahdi Afshari, and Mahshid Sattari, and Behzad Narouie, and Mehdi Sotoudeh, and Vahideh Montazeri, and Negar Sarhangi, and Mandana Hasanzad
December 2010, Yi chuan = Hereditas,
Paniz Khooshemehri, and Seyed Hamid Jamaldini, and Seyed Amir Mohsen Ziaee, and Mahdi Afshari, and Mahshid Sattari, and Behzad Narouie, and Mehdi Sotoudeh, and Vahideh Montazeri, and Negar Sarhangi, and Mandana Hasanzad
January 2023, Frontiers in genetics,
Paniz Khooshemehri, and Seyed Hamid Jamaldini, and Seyed Amir Mohsen Ziaee, and Mahdi Afshari, and Mahshid Sattari, and Behzad Narouie, and Mehdi Sotoudeh, and Vahideh Montazeri, and Negar Sarhangi, and Mandana Hasanzad
June 2022, Histopathology,
Copied contents to your clipboard!