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HLA-DR antigens and anticardiolipin antibodies in northern Italian systemic lupus erythematosus patients. 1988
M Savi, and
G F Ferraccioli, and
T M Neri, and
P Zanelli, and
P P Dall'Aglio, and
A Tincani, and
G Balestrieri, and
G Carella, and
R Cattaneo
Clinical Medicine and Nephrology Department, University of Parma, Italy.
Eighty systemic lupus erythematosus (SLE) patients attending 3 clinical centers were evaluated immunologically and immunogenetically. No HLA class II antigens were found to be significantly associated with SLE in these patients. A highly significant (P = 6.17 x 10(-7) association was observed between anticardiolipin antibodies and DR7. A lesser association (P less than 0.025) was also observed between DR2 and/or DR3 and anti-Ro (SS-A) antibodies. No relationship was found between any DR antigen and anti-Sm/RNP, anti-double-stranded DNA, or anti-La (SS-B) antibodies.
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