BIOMAT Database Logo BIOMAT Database Logo

Immunocytochemical localization of DNA adducts in rat tissues following treatment with N-nitrosomethylbenzylamine. 1988

J Van Benthem, and C P Wild, and E Vermeulen, and H H Winterwerp, and L Den Engelse, and E Scherer
Division of Chemical Carcinogenesis, The Netherlands Cancer Institute, Amsterdam.

Immunocytochemical visualization of O6-methylguanosine (meGua) and 7-meGua shows that DNA methylation by N-nitrosomethylbenzylamine(NMBzA) occurs not only in the target organs for tumour induction by this nitrosamine, the oesophagus and (occasionally) the tongue, but also in other tissues (liver, lung, trachea, tracheal glands and nasal cavity) for which no tumour induction by NMBzA has been reported. Thus, the organotropic carcinogenic action of NMBzA cannot be exclusively ascribed to differences in levels of DNA methylation. Additional determinants of the cancer risk in extra-oesophageal tissues could be the small size of the NMBzA-activating target cell population and a low proliferative activity.

UI MeSH Term Description Entries
D007150 Immunohistochemistry Histochemical localization of immunoreactive substances using labeled antibodies as reagents. Immunocytochemistry,Immunogold Techniques,Immunogold-Silver Techniques,Immunohistocytochemistry,Immunolabeling Techniques,Immunogold Technics,Immunogold-Silver Technics,Immunolabeling Technics,Immunogold Silver Technics,Immunogold Silver Techniques,Immunogold Technic,Immunogold Technique,Immunogold-Silver Technic,Immunogold-Silver Technique,Immunolabeling Technic,Immunolabeling Technique,Technic, Immunogold,Technic, Immunogold-Silver,Technic, Immunolabeling,Technics, Immunogold,Technics, Immunogold-Silver,Technics, Immunolabeling,Technique, Immunogold,Technique, Immunogold-Silver,Technique, Immunolabeling,Techniques, Immunogold,Techniques, Immunogold-Silver,Techniques, Immunolabeling
D008297 Male Males
D011919 Rats, Inbred Strains Genetically identical individuals developed from brother and sister matings which have been carried out for twenty or more generations or by parent x offspring matings carried out with certain restrictions. This also includes animals with a long history of closed colony breeding. August Rats,Inbred Rat Strains,Inbred Strain of Rat,Inbred Strain of Rats,Inbred Strains of Rats,Rat, Inbred Strain,August Rat,Inbred Rat Strain,Inbred Strain Rat,Inbred Strain Rats,Inbred Strains Rat,Inbred Strains Rats,Rat Inbred Strain,Rat Inbred Strains,Rat Strain, Inbred,Rat Strains, Inbred,Rat, August,Rat, Inbred Strains,Rats Inbred Strain,Rats Inbred Strains,Rats, August,Rats, Inbred Strain,Strain Rat, Inbred,Strain Rats, Inbred,Strain, Inbred Rat,Strains, Inbred Rat
D002273 Carcinogens Substances that increase the risk of NEOPLASMS in humans or animals. Both genotoxic chemicals, which affect DNA directly, and nongenotoxic chemicals, which induce neoplasms by other mechanism, are included. Carcinogen,Oncogen,Oncogens,Tumor Initiator,Tumor Initiators,Tumor Promoter,Tumor Promoters,Initiator, Tumor,Initiators, Tumor,Promoter, Tumor,Promoters, Tumor
D004128 Dimethylnitrosamine A nitrosamine derivative with alkylating, carcinogenic, and mutagenic properties. It causes serious liver damage and is a hepatocarcinogen in rodents. Nitrosodimethylamine,N-Nitrosodimethylamine,NDMA Nitrosodimethylamine,N Nitrosodimethylamine,Nitrosodimethylamine, NDMA
D004247 DNA A deoxyribonucleotide polymer that is the primary genetic material of all cells. Eukaryotic and prokaryotic organisms normally contain DNA in a double-stranded state, yet several important biological processes transiently involve single-stranded regions. DNA, which consists of a polysugar-phosphate backbone possessing projections of purines (adenine and guanine) and pyrimidines (thymine and cytosine), forms a double helix that is held together by hydrogen bonds between these purines and pyrimidines (adenine to thymine and guanine to cytosine). DNA, Double-Stranded,Deoxyribonucleic Acid,ds-DNA,DNA, Double Stranded,Double-Stranded DNA,ds DNA
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D051381 Rats The common name for the genus Rattus. Rattus,Rats, Laboratory,Rats, Norway,Rattus norvegicus,Laboratory Rat,Laboratory Rats,Norway Rat,Norway Rats,Rat,Rat, Laboratory,Rat, Norway,norvegicus, Rattus

Related Publications

J Van Benthem, and C P Wild, and E Vermeulen, and H H Winterwerp, and L Den Engelse, and E Scherer
Immunocytochemical analysis of carcinogen-DNA adducts in normal and preneoplastic tissues.
January 1991, Progress in histochemistry and cytochemistry,
J Van Benthem, and C P Wild, and E Vermeulen, and H H Winterwerp, and L Den Engelse, and E Scherer
Immunocytochemical localization of benzo(a)pyrene-DNA adducts in human tissue.
March 1988, Human pathology,
J Van Benthem, and C P Wild, and E Vermeulen, and H H Winterwerp, and L Den Engelse, and E Scherer
Immunocytochemical localization of corticosteroid-binding globulin in rat tissues.
January 1986, The Journal of endocrinology,
J Van Benthem, and C P Wild, and E Vermeulen, and H H Winterwerp, and L Den Engelse, and E Scherer
Immunocytochemical localization of ornithine aminotransferase in rat ocular tissues.
January 1987, Progress in clinical and biological research,
J Van Benthem, and C P Wild, and E Vermeulen, and H H Winterwerp, and L Den Engelse, and E Scherer
Immunocytochemical localization of ornithine aminotransferase in rat ocular tissues.
September 1987, Investigative ophthalmology & visual science,
J Van Benthem, and C P Wild, and E Vermeulen, and H H Winterwerp, and L Den Engelse, and E Scherer
Immunocytochemical localization of mitochondrial carbonic anhydrase in rat tissues.
April 1991, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society,
J Van Benthem, and C P Wild, and E Vermeulen, and H H Winterwerp, and L Den Engelse, and E Scherer
DNA methylation in specific cells of rat liver by N-nitrosodimethylamine and N-nitrosomethylbenzylamine.
July 1991, Carcinogenesis,
J Van Benthem, and C P Wild, and E Vermeulen, and H H Winterwerp, and L Den Engelse, and E Scherer
DNA methylation by N-nitrosomethylbenzylamine in target and non-target tissues of NMRI mice.
January 1981, Carcinogenesis,
J Van Benthem, and C P Wild, and E Vermeulen, and H H Winterwerp, and L Den Engelse, and E Scherer
Immunocytochemical localization of inhibin in rat and human reproductive tissues.
December 1987, Molecular and cellular endocrinology,
J Van Benthem, and C P Wild, and E Vermeulen, and H H Winterwerp, and L Den Engelse, and E Scherer
DNA methylation by N-nitrosomethylbenzylamine in target and non-target tissues of laboratory rodents. Comparison with carcinogenicity.
January 1984, IARC scientific publications,
Copied contents to your clipboard!