Biomaterial Database

FOXP3 rs2280883 polymorphism confers susceptibility to colorectal cancer in a Chinese Han population. 2020

Ying Lou, and Minhui Fan, and Renya Shuai, and Cheng Yao

Department of Medical Oncology, Zhuji People's Hospital of Zhejiang Province, The Zhuji affiliated Hospital of Shaoxing University, Zhuji, Zhejiang 311800, China.

Studies imply the FOXP3 gene polymorphisms are engaged in the occurrence of some cancers, but the relationship between FOXP3 rs2280883 polymorphism and the hazard of colorectal cancer (CRC) is unclear. For this reason, a case-control investigation involving 365 CRC patients and 411 healthy individuals (matched by both age and gender) was taken to illustrate the underlying association. FOXP3 rs2280883 polymorphism genotyped via PCR-RELP. Data revealed this polymorphism was significantly linked to increased risk for CRC (CC versus TT, OR, 1.75; 95%CI, 1.06-2.88; P = 0.030). Subgroup analyses uncovered FOXP3 rs2280883 polymorphism intensified the risk of CRC among smokers. As for the connection between rs2280883 and clinical data of CRC, this polymorphism corelated to lymph node metastasis (CC versus TT: OR, 2.75; 95%CI, 1.35-5.62; P = 0.004) and the TNM stage. In conclusion, FOXP3 rs2280883 polymorphism is related to higher risk of CRC in a Chinese individuals. Larger-sized studies involving other races are needed.

UI	MeSH Term	Description	Entries
D008297	Male		Males
D008875	Middle Aged	An adult aged 45 - 64 years.	Middle Age
D005260	Female		Females
D005838	Genotype	The genetic constitution of the individual, comprising the ALLELES present at each GENETIC LOCUS.	Genogroup,Genogroups,Genotypes
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000328	Adult	A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available.	Adults
D000368	Aged	A person 65 years of age or older. For a person older than 79 years, AGED, 80 AND OVER is available.	Elderly
D000369	Aged, 80 and over	Persons 80 years of age and older.	Oldest Old
D015179	Colorectal Neoplasms	Tumors or cancer of the COLON or the RECTUM or both. Risk factors for colorectal cancer include chronic ULCERATIVE COLITIS; FAMILIAL POLYPOSIS COLI; exposure to ASBESTOS; and irradiation of the CERVIX UTERI.	Colorectal Cancer,Colorectal Carcinoma,Colorectal Tumors,Neoplasms, Colorectal,Cancer, Colorectal,Cancers, Colorectal,Carcinoma, Colorectal,Carcinomas, Colorectal,Colorectal Cancers,Colorectal Carcinomas,Colorectal Neoplasm,Colorectal Tumor,Neoplasm, Colorectal,Tumor, Colorectal,Tumors, Colorectal
D016022	Case-Control Studies	Comparisons that start with the identification of persons with the disease or outcome of interest and a control (comparison, referent) group without the disease or outcome of interest. The relationship of an attribute is examined by comparing both groups with regard to the frequency or levels of outcome over time.	Case-Base Studies,Case-Comparison Studies,Case-Referent Studies,Matched Case-Control Studies,Nested Case-Control Studies,Case Control Studies,Case-Compeer Studies,Case-Referrent Studies,Case Base Studies,Case Comparison Studies,Case Control Study,Case Referent Studies,Case Referrent Studies,Case-Comparison Study,Case-Control Studies, Matched,Case-Control Studies, Nested,Case-Control Study,Case-Control Study, Matched,Case-Control Study, Nested,Case-Referent Study,Case-Referrent Study,Matched Case Control Studies,Matched Case-Control Study,Nested Case Control Studies,Nested Case-Control Study,Studies, Case Control,Studies, Case-Base,Studies, Case-Comparison,Studies, Case-Compeer,Studies, Case-Control,Studies, Case-Referent,Studies, Case-Referrent,Studies, Matched Case-Control,Studies, Nested Case-Control,Study, Case Control,Study, Case-Comparison,Study, Case-Control,Study, Case-Referent,Study, Case-Referrent,Study, Matched Case-Control,Study, Nested Case-Control