-transparent.png){kind=logo}
Improvement of pentobarbital-induced heart failure by MCI-154, a novel and potent cardiotonic agent, in the dog heart-lung preparation. 1988
Department of Pharmacology, Tohoku University School of Medicine, Sendai, Japan.
The efficacy of MCI-154, a new pyridazinone cardiotonic agent, in improving heart failure was assessed in dog heart-lung preparations in which cardiac function had been severely depressed by pentobarbital. MCI-154 in doses of 10-100 micrograms improved the cardiac function curve and restored it to the control level at 100 micrograms. At this dose, MCI-154 neither produced an increase in heart rate beyond the control value nor induced arrhythmias. The effects of MCI-154 were not affected by atenolol, a cardioselective beta 1-blocker. These results indicate that MCI-154 would be of potential use in the treatment of heart failure.
Related Publications
K Satoh, and
K Nunoki, and
T Goto, and
M Hosono, and
H Hashimoto, and
Y Sato, and
N Taira
January 1991,
European journal of pharmacology,
K Satoh, and
K Nunoki, and
T Goto, and
M Hosono, and
H Hashimoto, and
Y Sato, and
N Taira
February 1987,
European journal of pharmacology,
K Satoh, and
K Nunoki, and
T Goto, and
M Hosono, and
H Hashimoto, and
Y Sato, and
N Taira
December 1987,
Journal of cardiovascular pharmacology,
K Satoh, and
K Nunoki, and
T Goto, and
M Hosono, and
H Hashimoto, and
Y Sato, and
N Taira
March 1989,
Japanese journal of pharmacology,
K Satoh, and
K Nunoki, and
T Goto, and
M Hosono, and
H Hashimoto, and
Y Sato, and
N Taira
April 1992,
Japanese journal of pharmacology,
K Satoh, and
K Nunoki, and
T Goto, and
M Hosono, and
H Hashimoto, and
Y Sato, and
N Taira
January 1990,
European journal of pharmacology,
K Satoh, and
K Nunoki, and
T Goto, and
M Hosono, and
H Hashimoto, and
Y Sato, and
N Taira
May 1983,
Japanese heart journal,
K Satoh, and
K Nunoki, and
T Goto, and
M Hosono, and
H Hashimoto, and
Y Sato, and
N Taira
June 1992,
The Journal of pharmacology and experimental therapeutics,
K Satoh, and
K Nunoki, and
T Goto, and
M Hosono, and
H Hashimoto, and
Y Sato, and
N Taira
March 1997,
Journal of the American College of Cardiology,
K Satoh, and
K Nunoki, and
T Goto, and
M Hosono, and
H Hashimoto, and
Y Sato, and
N Taira
November 1987,
The Journal of pharmacology and experimental therapeutics,
