Biomaterial Database

Plasma levels of lidocaine following nebulized aerosol administration. 1977

W M Chinn, and D C Zavala, and J Ambre

The venous (plasma) levels of lidocaine were measured in five subjects following nebulization of a 280-mg dose via intermittent positive pressure breathing (IPPB) and nebulization of a 400-mg dose via ultrasound. Even though a lower dose of lidocaine was given by IPPB, this system of delivery produced higher plasma concentrations of the drug than ultrasound and also was more effective in eliminating the gag reflex. In the entire study, plasma concentrations of lidocaine did not exceed 1.1 mug/ml, which is far below toxic levels. Aerosolized lidocaine, administered by IPPB, is a safe and effective topical anesthetic agent which may be useful for instrumentation of the upper airway.

UI	MeSH Term	Description	Entries
D007384	Intermittent Positive-Pressure Breathing	Application of positive pressure to the inspiratory phase of spontaneous respiration.	IPPB,Inspiratory Positive-Pressure Breathing,Intermittent Positive Pressure Breathing (IPPB),Breathing, Inspiratory Positive-Pressure,Breathing, Intermittent Positive-Pressure,Inspiratory Positive Pressure Breathing,Intermittent Positive Pressure Breathing,Positive-Pressure Breathing, Inspiratory,Positive-Pressure Breathing, Intermittent
D008012	Lidocaine	A local anesthetic and cardiac depressant used as an antiarrhythmia agent. Its actions are more intense and its effects more prolonged than those of PROCAINE but its duration of action is shorter than that of BUPIVACAINE or PRILOCAINE.	Lignocaine,2-(Diethylamino)-N-(2,6-Dimethylphenyl)Acetamide,2-2EtN-2MePhAcN,Dalcaine,Lidocaine Carbonate,Lidocaine Carbonate (2:1),Lidocaine Hydrocarbonate,Lidocaine Hydrochloride,Lidocaine Monoacetate,Lidocaine Monohydrochloride,Lidocaine Monohydrochloride, Monohydrate,Lidocaine Sulfate (1:1),Octocaine,Xylesthesin,Xylocaine,Xylocitin,Xyloneural
D008297	Male		Males
D012137	Respiratory System	The tubular and cavernous organs and structures, by means of which pulmonary ventilation and gas exchange between ambient air and the blood are brought about.	Respiratory Tract,Respiratory Systems,Respiratory Tracts,System, Respiratory,Tract, Respiratory
D005069	Evaluation Studies as Topic	Works about studies that determine the effectiveness or value of processes, personnel, and equipment, or the material on conducting such studies.	Critique,Evaluation Indexes,Evaluation Methodology,Evaluation Report,Evaluation Research,Methodology, Evaluation,Pre-Post Tests,Qualitative Evaluation,Quantitative Evaluation,Theoretical Effectiveness,Use-Effectiveness,Critiques,Effectiveness, Theoretical,Evaluation Methodologies,Evaluation Reports,Evaluation, Qualitative,Evaluation, Quantitative,Evaluations, Qualitative,Evaluations, Quantitative,Indexes, Evaluation,Methodologies, Evaluation,Pre Post Tests,Pre-Post Test,Qualitative Evaluations,Quantitative Evaluations,Report, Evaluation,Reports, Evaluation,Research, Evaluation,Test, Pre-Post,Tests, Pre-Post,Use Effectiveness
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000328	Adult	A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available.	Adults
D000336	Aerosols	Colloids with a gaseous dispersing phase and either liquid (fog) or solid (smoke) dispersed phase; used in fumigation or in inhalation therapy; may contain propellant agents.	Aerosol
D000772	Anesthesia, Local	A blocking of nerve conduction to a specific area by an injection of an anesthetic agent.	Anesthesia, Infiltration,Local Anesthesia,Neural Therapy of Huneke,Huneke Neural Therapy,Infiltration Anesthesia
D013997	Time Factors	Elements of limited time intervals, contributing to particular results or situations.	Time Series,Factor, Time,Time Factor