Peripheral and central vestibular system findings in Meniere's disease. 2019

Selim Unsal, and Nebi Mustafa Gumus, and Mehmet Gunduz
Department of Audiology and Speech Pathology, Istinye University, Faculty of Health Sciences, Turkey Department of Audiology and Speech Pathology Istinye University Faculty of Health Sciences Turkey.

Meniere's Disease (MD) is a chronic disease that is characterized by intermittent episodes of tinnitus, vertigo, and progressivefluctuating sensorineural hearing loss together with aural fullness. The aim of this study is to evaluate Meniere's disease patients with vestibular test battery as Videonystagmography (VNG), Vestibular Evoked Myogenic Potentials (VEMPs) and Video Head Impulse Test (V-HIT) to assess peripheral and central vestibular systems. 16 bilateral, 17 unilateral patients suffering from MD (mean age, 40.90 years, range, 23 to 66 years; 20 women and 13 men) comprised the study group, and 39 healthy (mean age, 38.10 years, range from 21 to 60 years; 22 women and 17 men) volunteers formed control group. Evaluation of peripheral and central vestibular systems changes with oculomotor tests, caloric test, C-VEMPs, O-VEMPs, and the evaluation of the vestibular ocular reflex (VOR) using the V-HIT. Twenty-six ears out of the forty-nine ears that were affected by Meniere's disease were diagnosed as otolith or ampullary dysfunction. As to O-VEMPs testing, N1 and P1 waves could not be obtained from thirty of the forty-nine ears affected by Meniere's disease. As for obtained N1 and P1 waves, prolonged N1 and P1 wave latencies, and reduced amplitude was observed in Meniere's group. P1 and N1 waves were not observed in 5 bilateral and 2 unilateral Meniere's patients (12 ears out of 49 affected ears) in C-VEMPs recordings (23.9%). In Meniere's patients' group, 44.9% of the velocity gain values were obtained in the pathologic borders of v- HIT. In addition to lower velocity gain, higher ratios of asymmetry were obtained from the ears affected with Meniere's disease. According to these results, it can be concluded that Meniere's disease significantly affects the peripheral vestibular system but the functions of the central vestibular system were not affected.

UI MeSH Term Description Entries
D008297 Male Males
D008575 Meniere Disease A disease of the inner ear (LABYRINTH) that is characterized by fluctuating SENSORINEURAL HEARING LOSS; TINNITUS; episodic VERTIGO; and aural fullness. It is the most common form of endolymphatic hydrops. Meniere's Disease,Meniere's Syndrome,Vertigo, Aural,Auditory Vertigo,Aural Vertigo,Ménière Disease,Ménière's Disease,Ménière's Vertigo,Otogenic Vertigo,Auditory Vertigos,Disease, Meniere,Disease, Meniere's,Disease, Ménière,Disease, Ménière's,Diseases, Ménière,Diseases, Ménière's,Meniere Syndrome,Menieres Disease,Menieres Syndrome,Ménière Diseases,Ménière Vertigo,Ménière's Diseases,Ménière's Vertigos,Ménières Disease,Ménières Vertigo,Otogenic Vertigos,Syndrome, Meniere's,Vertigo, Auditory,Vertigo, Ménière's,Vertigo, Otogenic,Vertigos, Auditory,Vertigos, Ménière's,Vertigos, Otogenic
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D003430 Cross-Sectional Studies Studies in which the presence or absence of disease or other health-related variables are determined in each member of the study population or in a representative sample at one particular time. This contrasts with LONGITUDINAL STUDIES which are followed over a period of time. Disease Frequency Surveys,Prevalence Studies,Analysis, Cross-Sectional,Cross Sectional Analysis,Cross-Sectional Survey,Surveys, Disease Frequency,Analyses, Cross Sectional,Analyses, Cross-Sectional,Analysis, Cross Sectional,Cross Sectional Analyses,Cross Sectional Studies,Cross Sectional Survey,Cross-Sectional Analyses,Cross-Sectional Analysis,Cross-Sectional Study,Cross-Sectional Surveys,Disease Frequency Survey,Prevalence Study,Studies, Cross-Sectional,Studies, Prevalence,Study, Cross-Sectional,Study, Prevalence,Survey, Cross-Sectional,Survey, Disease Frequency,Surveys, Cross-Sectional
D005260 Female Females
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000328 Adult A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available. Adults
D000368 Aged A person 65 years of age or older. For a person older than 79 years, AGED, 80 AND OVER is available. Elderly
D014724 Vestibular Function Tests A number of tests used to determine if the brain or balance portion of the inner ear are causing dizziness. Function Test, Vestibular,Function Tests, Vestibular,Test, Vestibular Function,Tests, Vestibular Function,Vestibular Function Test
D055815 Young Adult A person between 19 and 24 years of age. Adult, Young,Adults, Young,Young Adults

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