BIOMAT Database Logo BIOMAT Database Logo

Aldehyde as a Traceless Directing Group for Regioselective C-H Alkylation Catalyzed by Rhodium(III) in Air. 2020

Si-Qi Chen, and Xin-Ran Li, and Chao-Jun Li, and Juan Fan, and Zhong-Wen Liu, and Xian-Ying Shi
Key Laboratory of Syngas Conversion of Shaanxi Province, Key Laboratory for Macromolecular Science of Shaanxi Province, Key Laboratory of Applied Surface and Colloid Chemistry (Ministry of Education), School of Chemistry and Chemical Engineering , Shaanxi Normal University , Xi'an 710062 , China.

The aromatic aldehyde as a traceless directing group for the regionselective C-H alkylation catalyzed by rhodium(III) under aerobic atmospheric conditions has been developed. The process involves an aldehyde assisted direct addition of C-H bond to unsaturated electrophiles of acrylates or acrylic acids, and the subsequent decarbonylation. A trace amount of water is found to favor the reaction.

UI MeSH Term Description Entries

Related Publications

Si-Qi Chen, and Xin-Ran Li, and Chao-Jun Li, and Juan Fan, and Zhong-Wen Liu, and Xian-Ying Shi
Rhodium(i)-catalyzed cascade C(sp2)-H bond alkylation - amidation of anilines: phosphorus as traceless directing group.
August 2023, Chemical science,
Si-Qi Chen, and Xin-Ran Li, and Chao-Jun Li, and Juan Fan, and Zhong-Wen Liu, and Xian-Ying Shi
Carboxylic acids as traceless directing groups for the rhodium(III)-catalyzed decarboxylative C-H arylation of thiophenes.
March 2015, Angewandte Chemie (International ed. in English),
Si-Qi Chen, and Xin-Ran Li, and Chao-Jun Li, and Juan Fan, and Zhong-Wen Liu, and Xian-Ying Shi
Rhodium-Catalyzed C4-Selective C-H Alkenylation of 2-Pyridones by Traceless Directing Group Strategy.
February 2021, Organic letters,
Si-Qi Chen, and Xin-Ran Li, and Chao-Jun Li, and Juan Fan, and Zhong-Wen Liu, and Xian-Ying Shi
Aldehyde as a Traceless Directing Group for Rh(III)-Catalyzed C-H Activation: A Facile Access to Diverse Indolo[1,2-a]quinolines.
June 2015, Organic letters,
Si-Qi Chen, and Xin-Ran Li, and Chao-Jun Li, and Juan Fan, and Zhong-Wen Liu, and Xian-Ying Shi
Redox-Neutral Manganese(I)-Catalyzed C-H Activation: Traceless Directing Group Enabled Regioselective Annulation.
October 2017, Angewandte Chemie (International ed. in English),
Si-Qi Chen, and Xin-Ran Li, and Chao-Jun Li, and Juan Fan, and Zhong-Wen Liu, and Xian-Ying Shi
Nitrone Directing Groups in Rhodium(III)-Catalyzed C-H Activation of Arenes: 1,3-Dipoles versus Traceless Directing Groups.
December 2016, Angewandte Chemie (International ed. in English),
Si-Qi Chen, and Xin-Ran Li, and Chao-Jun Li, and Juan Fan, and Zhong-Wen Liu, and Xian-Ying Shi
N-oxide as a traceless oxidizing directing group: mild rhodium(III)-catalyzed C-H olefination for the synthesis of ortho-alkenylated tertiary anilines.
December 2013, Angewandte Chemie (International ed. in English),
Si-Qi Chen, and Xin-Ran Li, and Chao-Jun Li, and Juan Fan, and Zhong-Wen Liu, and Xian-Ying Shi
Rhodium-Catalyzed C2-Alkylation of Indoles with Cyclopropanols Using N,N-Dialkylcarbamoyl as a Traceless Directing Group.
September 2022, Organic letters,
Si-Qi Chen, and Xin-Ran Li, and Chao-Jun Li, and Juan Fan, and Zhong-Wen Liu, and Xian-Ying Shi
Directing group strategies in rhodium-catalyzed C-H amination.
October 2022, Organic & biomolecular chemistry,
Si-Qi Chen, and Xin-Ran Li, and Chao-Jun Li, and Juan Fan, and Zhong-Wen Liu, and Xian-Ying Shi
A traceless directing group for C-H borylation.
December 2013, Angewandte Chemie (International ed. in English),
Copied contents to your clipboard!