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In a study of the kinetics and metabolic interaction of xylene and methyl ethyl ketone (MEK) eight male volunteers were exposed to m-xylene (100 ppm) and MEK (200 ppm). The exposures to the two compounds were carried out both separately and in combination. Respiratory uptake and blood concentration, as well as urinary metabolites (methyl hippuric acid and 2,3-butanediol), were monitored. Coexposure to xylene and MEK resulted in inhibited xylene metabolism. The xylene concentration in blood increased significantly, and the urinary excretion of methyl hippuric acid decreased. The combined exposure did not cause any change in the concentration of MEK in the blood or the excretion of 2,3-butanediol in the urine. Exposure to MEK 20 h before the m-xylene exposure had no detectable effect on the kinetics of m-xylene.
J Liira, and
V Riihimäki, and
K Engström, and
P Pfäffli
June 1997,
Toxicology and applied pharmacology,
J Liira, and
V Riihimäki, and
K Engström, and
P Pfäffli
February 1985,
British journal of industrial medicine,
J Liira, and
V Riihimäki, and
K Engström, and
P Pfäffli
February 1985,
British journal of industrial medicine,
J Liira, and
V Riihimäki, and
K Engström, and
P Pfäffli
March 1998,
International archives of occupational and environmental health,
J Liira, and
V Riihimäki, and
K Engström, and
P Pfäffli
February 1988,
British journal of industrial medicine,
J Liira, and
V Riihimäki, and
K Engström, and
P Pfäffli
January 1988,
Reviews of environmental contamination and toxicology,
J Liira, and
V Riihimäki, and
K Engström, and
P Pfäffli
January 1984,
International archives of occupational and environmental health,
J Liira, and
V Riihimäki, and
K Engström, and
P Pfäffli
December 1993,
Environmental health perspectives,
J Liira, and
V Riihimäki, and
K Engström, and
P Pfäffli
December 1948,
Journal of the American Chemical Society,
J Liira, and
V Riihimäki, and
K Engström, and
P Pfäffli
March 1952,
Gazzetta medica italiana,
