High resolution nuclear magnetic resonance imaging of the spinal cord in experimental demyelinating disease. 1988

G V Peersman, and F L Van de Vyver, and J E Lohman, and U Lübke, and J Gheuens, and E Bellon, and A Connelly, and J J Martin
Laboratory of Neuropathology, Born-Bunge Foundation, University of Antwerp, Wilrijk, Belgium.

Chronic recurrent experimental allergic encephalomyelitis was induced in a strain 13 guinea pig by inoculation of isologous spinal cord homogenate. The spinal cord was obtained after perfusion with 4% paraformaldehyde and examined with nuclear magnetic resonance (NMR) imaging. Proton NMR spin echo images (repetition time: 3 s; echo times: 20 and 60 ms) were obtained from intact, isolated spinal cord in a 4.7 Tesla, 50 mm bore magnet. The slice thickness of the images was 380 microns and the inplane resolution was 40 X 40 microns. The images showed superficial areas of low signal intensity in the lateroventral regions of the white matter, in some instances with a seam of higher signal intensity. Neuropathologically, these abnormalities corresponded exactly to areas of demyelination. Control images did not show these abnormalities. The present high resolution imaging allowed a correlation between demyelination and abnormal NMR signals in a small laboratory animal with an inflammatory demyelinating disease.

UI MeSH Term Description Entries
D008279 Magnetic Resonance Imaging Non-invasive method of demonstrating internal anatomy based on the principle that atomic nuclei in a strong magnetic field absorb pulses of radiofrequency energy and emit them as radiowaves which can be reconstructed into computerized images. The concept includes proton spin tomographic techniques. Chemical Shift Imaging,MR Tomography,MRI Scans,MRI, Functional,Magnetic Resonance Image,Magnetic Resonance Imaging, Functional,Magnetization Transfer Contrast Imaging,NMR Imaging,NMR Tomography,Tomography, NMR,Tomography, Proton Spin,fMRI,Functional Magnetic Resonance Imaging,Imaging, Chemical Shift,Proton Spin Tomography,Spin Echo Imaging,Steady-State Free Precession MRI,Tomography, MR,Zeugmatography,Chemical Shift Imagings,Echo Imaging, Spin,Echo Imagings, Spin,Functional MRI,Functional MRIs,Image, Magnetic Resonance,Imaging, Magnetic Resonance,Imaging, NMR,Imaging, Spin Echo,Imagings, Chemical Shift,Imagings, Spin Echo,MRI Scan,MRIs, Functional,Magnetic Resonance Images,Resonance Image, Magnetic,Scan, MRI,Scans, MRI,Shift Imaging, Chemical,Shift Imagings, Chemical,Spin Echo Imagings,Steady State Free Precession MRI
D003711 Demyelinating Diseases Diseases characterized by loss or dysfunction of myelin in the central or peripheral nervous system. Clinically Isolated CNS Demyelinating Syndrome,Clinically Isolated Syndrome, CNS Demyelinating,Demyelinating Disorders,Demyelination,Demyelinating Disease,Demyelinating Disorder,Demyelinations
D004195 Disease Models, Animal Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases. Animal Disease Model,Animal Disease Models,Disease Model, Animal
D006168 Guinea Pigs A common name used for the genus Cavia. The most common species is Cavia porcellus which is the domesticated guinea pig used for pets and biomedical research. Cavia,Cavia porcellus,Guinea Pig,Pig, Guinea,Pigs, Guinea
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D013116 Spinal Cord A cylindrical column of tissue that lies within the vertebral canal. It is composed of WHITE MATTER and GRAY MATTER. Coccygeal Cord,Conus Medullaris,Conus Terminalis,Lumbar Cord,Medulla Spinalis,Myelon,Sacral Cord,Thoracic Cord,Coccygeal Cords,Conus Medullari,Conus Terminali,Cord, Coccygeal,Cord, Lumbar,Cord, Sacral,Cord, Spinal,Cord, Thoracic,Cords, Coccygeal,Cords, Lumbar,Cords, Sacral,Cords, Spinal,Cords, Thoracic,Lumbar Cords,Medulla Spinali,Medullari, Conus,Medullaris, Conus,Myelons,Sacral Cords,Spinal Cords,Spinali, Medulla,Spinalis, Medulla,Terminali, Conus,Terminalis, Conus,Thoracic Cords

Related Publications

G V Peersman, and F L Van de Vyver, and J E Lohman, and U Lübke, and J Gheuens, and E Bellon, and A Connelly, and J J Martin
September 1992, Neurosurgery,
G V Peersman, and F L Van de Vyver, and J E Lohman, and U Lübke, and J Gheuens, and E Bellon, and A Connelly, and J J Martin
October 1996, Neurological research,
G V Peersman, and F L Van de Vyver, and J E Lohman, and U Lübke, and J Gheuens, and E Bellon, and A Connelly, and J J Martin
November 1983, Bulletin de la Societe belge d'ophtalmologie,
G V Peersman, and F L Van de Vyver, and J E Lohman, and U Lübke, and J Gheuens, and E Bellon, and A Connelly, and J J Martin
July 1998, Spine,
G V Peersman, and F L Van de Vyver, and J E Lohman, and U Lübke, and J Gheuens, and E Bellon, and A Connelly, and J J Martin
June 1990, Magnetic resonance in medicine,
G V Peersman, and F L Van de Vyver, and J E Lohman, and U Lübke, and J Gheuens, and E Bellon, and A Connelly, and J J Martin
January 1994, Neurologia i neurochirurgia polska,
G V Peersman, and F L Van de Vyver, and J E Lohman, and U Lübke, and J Gheuens, and E Bellon, and A Connelly, and J J Martin
January 1967, Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme,
G V Peersman, and F L Van de Vyver, and J E Lohman, and U Lübke, and J Gheuens, and E Bellon, and A Connelly, and J J Martin
October 1993, Spine,
G V Peersman, and F L Van de Vyver, and J E Lohman, and U Lübke, and J Gheuens, and E Bellon, and A Connelly, and J J Martin
August 1986, Pediatrics,
G V Peersman, and F L Van de Vyver, and J E Lohman, and U Lübke, and J Gheuens, and E Bellon, and A Connelly, and J J Martin
May 1985, The Journal of the Medical Society of New Jersey,
Copied contents to your clipboard!