Biomaterial Database

Enterotoxigenic Escherichia coli isolated from patients at a hospital in Dacca. 1977

D A Sack, and J C McLaughlin, and R B Sack, and F Orskov, and I Orskov

Enterotoxigenic strains of Escherichia coli, a significant cause of acute, watery, cholera-like diarrhea, were isolated from 23 of 65 patients with diarrhea in whom no other enteric pathogens were found during one week (November 1974) at the Cholera Research Hospital, Dacca, Bangladesh. Diarrhea associated with enterotoxigenic strains of E. coli occurred primarily in adults but affected persons of all age groups and could not be distinguished from cholera or from other cholera-like diarrhea on clinical grounds. Routine bacteriologic methods were inadequate for identification of enterotoxigenic E. coli as the etiologic agent of the diarrhea. The enterotoxigenic E. coli, producing heat-stable and/or heat-labile enterotoxin, were detected by use of assays in the Y1 adrenal cell, the Chinese hamster ovary cell, the rabbit ileal loop, and the infant mouse. The two tissue culture assays yielded comparable results in tests with 640 (193 positive, 447 negative) of 643 isolates of E. coli. The results of this study support the idea that enterotoxigenic E. coli play a significant role as pathogens in the etiology of acute watery diarrhea.

UI	MeSH Term	Description	Entries
D007223	Infant	A child between 1 and 23 months of age.	Infants
D008875	Middle Aged	An adult aged 45 - 64 years.	Middle Age
D002648	Child	A person 6 to 12 years of age. An individual 2 to 5 years old is CHILD, PRESCHOOL.	Children
D002675	Child, Preschool	A child between the ages of 2 and 5.	Children, Preschool,Preschool Child,Preschool Children
D002771	Cholera	An acute diarrheal disease endemic in India and Southeast Asia whose causative agent is VIBRIO CHOLERAE. This condition can lead to severe dehydration in a matter of hours unless quickly treated.	Vibrio cholerae Infection,Choleras,Infection, Vibrio cholerae,Infections, Vibrio cholerae,Vibrio cholerae Infections
D003937	Diagnosis, Differential	Determination of which one of two or more diseases or conditions a patient is suffering from by systematically comparing and contrasting results of diagnostic measures.	Diagnoses, Differential,Differential Diagnoses,Differential Diagnosis
D003967	Diarrhea	An increased liquidity or decreased consistency of FECES, such as running stool. Fecal consistency is related to the ratio of water-holding capacity of insoluble solids to total water, rather than the amount of water present. Diarrhea is not hyperdefecation or increased fecal weight.	Diarrheas
D004768	Enterotoxins	Substances that are toxic to the intestinal tract causing vomiting, diarrhea, etc.; most common enterotoxins are produced by bacteria.	Staphylococcal Enterotoxin,Enterotoxin,Staphylococcal Enterotoxins,Enterotoxin, Staphylococcal,Enterotoxins, Staphylococcal
D004926	Escherichia coli	A species of gram-negative, facultatively anaerobic, rod-shaped bacteria (GRAM-NEGATIVE FACULTATIVELY ANAEROBIC RODS) commonly found in the lower part of the intestine of warm-blooded animals. It is usually nonpathogenic, but some strains are known to produce DIARRHEA and pyogenic infections. Pathogenic strains (virotypes) are classified by their specific pathogenic mechanisms such as toxins (ENTEROTOXIGENIC ESCHERICHIA COLI), etc.	Alkalescens-Dispar Group,Bacillus coli,Bacterium coli,Bacterium coli commune,Diffusely Adherent Escherichia coli,E coli,EAggEC,Enteroaggregative Escherichia coli,Enterococcus coli,Diffusely Adherent E. coli,Enteroaggregative E. coli,Enteroinvasive E. coli,Enteroinvasive Escherichia coli
D004927	Escherichia coli Infections	Infections with bacteria of the species ESCHERICHIA COLI.	E coli Infections,E. coli Infection,Infections, E coli,Infections, Escherichia coli,E coli Infection,E. coli Infections,Escherichia coli Infection,Infection, E coli,Infection, E. coli,Infection, Escherichia coli