OBJECTIVE To investigate simulated localized and generalized wear of self-adhesive restorative materials. METHODS Three commercially available restorative materials and one experimental material with self-adhesive properties were evaluated. The experimental material was tested in both light-cured and self-cured conditions. Activa (A), Fuji II LC (F), and Equia Forte (E) and the experimental material ASAR-MP4 (S) were investigated. Two kinds of wear were simulated in an Alabama wear machine. Localized wear was simulated with a stainless-steel ball bearing antagonist and generalized with a flat-ended stainless-steel cylinder antagonist. The wear challenge was carried out in an aqueous slurry of polymethyl methacrylate beads. Material volume loss was measured on polyvinyl siloxane replicates of each worn surface using a Proscan 2100 noncontact profilometer in conjunction with Proscan and AnSur 3D software. RESULTS There were significant differences (p < 0.05) among the materials for both generalized and localized wear. The experimental material in both curing modes exhibited significantly less localized wear than F and A and significantly less generalized wear than F and E. CONCLUSIONS Self-adhesive materials offer unique handling properties for direct placement of posterior restorations in permanent teeth. The experimental material ASAR-MP4 generated similar wear values to the other self-adhesive materials tested.