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1. The efficacy of felodipine a new calcium channel blocker with selective vasodilator activity in the management of severe low output cardiac failure, secondary to coronary heart disease, was determined in 10 patients. 2. Haemodynamic measurements were made at rest and during dynamic exercise and left ventricular function was assessed by radionuclide ventriculography. 3. Significant increases in cardiac index, stroke volume index and ejection fraction were found particularly during exercise, both acutely and following 4 weeks administration of felodipine therapy. 4. Felodipine could well have a significant role in the long term management of the patient with chronic cardiac failure.
A C Tweddel, and
W Martin, and
A I McGhie, and
I Hutton
August 1987,
British heart journal,
A C Tweddel, and
W Martin, and
A I McGhie, and
I Hutton
January 1987,
Drugs,
A C Tweddel, and
W Martin, and
A I McGhie, and
I Hutton
January 1985,
European journal of clinical pharmacology,
A C Tweddel, and
W Martin, and
A I McGhie, and
I Hutton
January 1987,
Drugs,
A C Tweddel, and
W Martin, and
A I McGhie, and
I Hutton
April 1984,
British heart journal,
A C Tweddel, and
W Martin, and
A I McGhie, and
I Hutton
January 1985,
Drugs,
A C Tweddel, and
W Martin, and
A I McGhie, and
I Hutton
January 1985,
Drugs,
A C Tweddel, and
W Martin, and
A I McGhie, and
I Hutton
January 1986,
Indian heart journal,
A C Tweddel, and
W Martin, and
A I McGhie, and
I Hutton
October 1983,
Journal of hypertension. Supplement : official journal of the International Society of Hypertension,
A C Tweddel, and
W Martin, and
A I McGhie, and
I Hutton
January 1988,
Current medical research and opinion,
