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A patient is described who had typical pemphigus vegetans, according to clinical, histopathological and immunofluorescence criteria. To determine the specific molecules bound by antibodies in the serum of this patient, an immunoprecipitation analysis was performed with extracts of [14C]-amino acid labelled cultured normal human keratinocytes. The patient's serum precipitated the 130 kd and 85 kd polypeptides of the pemphigus vulgaris antigen, but also precipitated other polypeptides, the significance of which is not clear.
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